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• W2011939940 abstract "No AccessJournal of UrologyINVESTIGATIVE UROLOGY1 Jul 2001INVOLVEMENT OF HYPOGASTRIC AND PELVIC NERVES FOR CONVEYING CYSTITIS INDUCED NOCICEPTION IN CONSCIOUS RATS MURIELLE MEEN, MARIE-ANGE COUDORE-CIVIALE, ALAIN ESCHALIER, and MICHEL BOUCHER MURIELLE MEENMURIELLE MEEN More articles by this author , MARIE-ANGE COUDORE-CIVIALEMARIE-ANGE COUDORE-CIVIALE More articles by this author , ALAIN ESCHALIERALAIN ESCHALIER More articles by this author , and MICHEL BOUCHERMICHEL BOUCHER More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)66152-6AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We determined the sites of the antinociceptive action of morphine in the experimental model of cyclophosphamide induced cystitis and investigated the afferent nerve fibers involved in nociception transmission originating from the bladder. Materials and Methods: Cyclophosphamide (200 mg./kg.) given intraperitoneally was used to induce cystitis in male rats and their behavior was observed and scored. The effect of 2 mg./kg. systemic morphine given intravenously on cyclophosphamide induced behavioral modifications was tested when administered alone and after 100 μg. naloxone per rat given intrathecally at the L1 to L2 or L6 to S1 level. The spinal antinociceptive effect of morphine was also tested when administered intrathecally alone at 10, 100 and 200 μg. per rat at L1 to L2, alone at 100 μg. per rat at L1 to L2 or L6 to S1, alone at 100 μg. per rat at L1 to L2 and L6 to S1 simultaneously, alone at 200 μg. per rat at L1 to L2 and after 100 μg. naloxone per rat given intrathecally at L6 to S1 at 100 μg. per rat at L1 to L2. Results: Cyclophosphamide induced marked modifications in the behavior of the rats, including a decreased breathing rate, eye closing and specific postures. Morphine given intravenously reversed these behavioral disorders and this reversal was completely prevented by pretreatment with intrathecal naloxone. A dose of 100 μg. per rat given intrathecally also reversed these behavioral disorders by about 25% at the L1 to L2 and L6 to S1 levels. In addition, a dose of 100 μg. morphine per rat administered intrathecally and simultaneously at L1 to L2 and L6 to S1 produced an effect equal to the sum of those observed when administered separately, that is about 50%, whereas morphine at an intrathecal dose of 200 μg. at L1 to L2 produced the same effect as 100 μg. given intrathecally at the same level or at L6 to S1 (25%). Also, 100 μg. naloxone per rat administered intrathecally at L6 to S1 prevented the effect of 100 μg. morphine at L1 to L2. Conclusions: These results confirm the previously reported antinociceptive effect of systemic morphine in this model of cyclophosphamide cystitis, suggest that this antinociceptive action is completely located at the spinal site and most importantly demonstrate by the pharmacological approach and behavioral analysis that nociceptive sensations originating from the bladder are conveyed by hypogastric and pelvic nerves in this cyclophosphamide cystitis model in the conscious rat. References 1 : A model for the study of visceral pain states: chronic inflammation of the chronic decerebrate rat urinary bladder by irritant chemicals. Pain1987; 28: 109. Google Scholar 2 : The contribution of sensory nerves to xylene-induced cystitis in rats. Neuroscience1988; 26: 709. Google Scholar 3 : Neuronal and behavioural consequences of chemical inflammation of rat urinary bladder. Agents Actions1988; 25: 231. 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Google Scholar From the INSERM EPI 9904, Laboratoire de Physiologie, Faculté de Pharmacie and Laboratoire de Pharmacologie Médicale, Faculté de Médecine, Clermont-Ferrand Cedex, France© 2001 by American Urological Association, Inc.FiguresReferencesRelatedDetails Volume 166Issue 1July 2001Page: 318-322 Advertisement Copyright & Permissions© 2001 by American Urological Association, Inc.Keywordsrats, Sprague-Dawleycystitispain measurementcyclophosphamidebladderMetricsAuthor Information MURIELLE MEEN More articles by this author MARIE-ANGE COUDORE-CIVIALE More articles by this author ALAIN ESCHALIER More articles by this author MICHEL BOUCHER More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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