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- W2011940177 endingPage "173" @default.
- W2011940177 startingPage "163" @default.
- W2011940177 abstract "During histogenesis of the vertebrate central nervous system (CNS), neuronal progenitors must interact with germinal zone (GZ) niches, differentiate, and morphologically mature, and neurons must migrate to their final positions. The extrinsic cues that control neurogenesis, specify neurons, and guide their movement are relatively well understood. However, less is known about how neurons spatiotemporally modify cell–cell interactions and cell polarization to navigate through complex, distinct cellular environments during neuronal circuit formation. Here we examine the parallels between the mechanisms controlling epithelial morphogenesis and the cell adhesion events by which neural cells organize GZ niches and direct neuronal migration. We focus on the emerging relationship between neuronal adhesive interactions and conserved cell-polarity signaling cascades. During histogenesis of the vertebrate central nervous system (CNS), neuronal progenitors must interact with germinal zone (GZ) niches, differentiate, and morphologically mature, and neurons must migrate to their final positions. The extrinsic cues that control neurogenesis, specify neurons, and guide their movement are relatively well understood. However, less is known about how neurons spatiotemporally modify cell–cell interactions and cell polarization to navigate through complex, distinct cellular environments during neuronal circuit formation. Here we examine the parallels between the mechanisms controlling epithelial morphogenesis and the cell adhesion events by which neural cells organize GZ niches and direct neuronal migration. We focus on the emerging relationship between neuronal adhesive interactions and conserved cell-polarity signaling cascades." @default.
- W2011940177 created "2016-06-24" @default.
- W2011940177 creator A5033777669 @default.
- W2011940177 creator A5083885755 @default.
- W2011940177 date "2013-03-01" @default.
- W2011940177 modified "2023-10-03" @default.
- W2011940177 title "New spin on an old transition: epithelial parallels in neuronal adhesion control" @default.
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