Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011946110> ?p ?o ?g. }
- W2011946110 endingPage "61" @default.
- W2011946110 startingPage "54" @default.
- W2011946110 abstract "Using the mouse prostate reconstitution (MPR) model system, under conditions where the ras and myc oncogenes are introduced via a recombinant retrovirus into both the mesenchymal and epithelial compartments of the urogenital sinus, poorly differentiated prostate cancer is produced with high frequency (>90%) using inbred C57BL/6 mice. Northern blotting and immunohistochemical analysis showed that the transition from benign prostatic hyperplasia (BPH) to prostate cancer is invariably associated with the induction of elevated transforming growth factor-β1 (TGF-β1) expression. Similar analysis of TGF-β1 in human BPH and prostate cancer is consistent with our MPR results and indicates that the accumulation of extracellular TGF-β1 is significantly more intense in prostate cancer compared to normal or benign prostate tissues. Interestingly, where benign pathologies are observed in the prostatic stroma in the presence of benign prostatic epithelium, extracellular TGF-β1 is seen predominantly in the stromal compartment. Experimental studies clearly demonstrate that mRNA levels of TGF-β1 and other growth related genes are regulated by androgens in prostate cancer cells. Overall, our results suggest that elevated TGF-β1 is involved in the development of prostate cancer. Direct determination of TGF-β1 levels and distribution as well as analysis of localized and systemic effects produced by TGF-β1 may serve as useful biomarkers for prostate cancer. © 1992 Wiley-Liss, Inc." @default.
- W2011946110 created "2016-06-24" @default.
- W2011946110 creator A5000376423 @default.
- W2011946110 creator A5007266497 @default.
- W2011946110 creator A5012224683 @default.
- W2011946110 creator A5018850018 @default.
- W2011946110 creator A5042000405 @default.
- W2011946110 creator A5072634480 @default.
- W2011946110 creator A5083409230 @default.
- W2011946110 creator A5014963741 @default.
- W2011946110 date "1992-01-01" @default.
- W2011946110 modified "2023-09-23" @default.
- W2011946110 title "Transforming growth factor β1 as a biomarker for prostate cancer" @default.
- W2011946110 cites W143417350 @default.
- W2011946110 cites W1505978562 @default.
- W2011946110 cites W1543126301 @default.
- W2011946110 cites W1852725426 @default.
- W2011946110 cites W1971874426 @default.
- W2011946110 cites W1975514073 @default.
- W2011946110 cites W1977799444 @default.
- W2011946110 cites W1979673654 @default.
- W2011946110 cites W1984172347 @default.
- W2011946110 cites W1988916808 @default.
- W2011946110 cites W1992172901 @default.
- W2011946110 cites W2014418134 @default.
- W2011946110 cites W2035159808 @default.
- W2011946110 cites W2035244457 @default.
- W2011946110 cites W2045208557 @default.
- W2011946110 cites W2051877942 @default.
- W2011946110 cites W2052357987 @default.
- W2011946110 cites W2060516416 @default.
- W2011946110 cites W2072320617 @default.
- W2011946110 cites W2080891648 @default.
- W2011946110 cites W2087272945 @default.
- W2011946110 cites W2089923904 @default.
- W2011946110 cites W2093500426 @default.
- W2011946110 cites W2099941826 @default.
- W2011946110 cites W2099985524 @default.
- W2011946110 cites W2118857294 @default.
- W2011946110 cites W2159579113 @default.
- W2011946110 cites W2161914250 @default.
- W2011946110 cites W2168476587 @default.
- W2011946110 cites W2267688072 @default.
- W2011946110 cites W4211095094 @default.
- W2011946110 doi "https://doi.org/10.1002/jcb.240501212" @default.
- W2011946110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1289674" @default.
- W2011946110 hasPublicationYear "1992" @default.
- W2011946110 type Work @default.
- W2011946110 sameAs 2011946110 @default.
- W2011946110 citedByCount "68" @default.
- W2011946110 countsByYear W20119461102012 @default.
- W2011946110 countsByYear W20119461102013 @default.
- W2011946110 countsByYear W20119461102014 @default.
- W2011946110 countsByYear W20119461102015 @default.
- W2011946110 countsByYear W20119461102016 @default.
- W2011946110 countsByYear W20119461102017 @default.
- W2011946110 crossrefType "journal-article" @default.
- W2011946110 hasAuthorship W2011946110A5000376423 @default.
- W2011946110 hasAuthorship W2011946110A5007266497 @default.
- W2011946110 hasAuthorship W2011946110A5012224683 @default.
- W2011946110 hasAuthorship W2011946110A5014963741 @default.
- W2011946110 hasAuthorship W2011946110A5018850018 @default.
- W2011946110 hasAuthorship W2011946110A5042000405 @default.
- W2011946110 hasAuthorship W2011946110A5072634480 @default.
- W2011946110 hasAuthorship W2011946110A5083409230 @default.
- W2011946110 hasConcept C118131993 @default.
- W2011946110 hasConcept C121608353 @default.
- W2011946110 hasConcept C126322002 @default.
- W2011946110 hasConcept C142724271 @default.
- W2011946110 hasConcept C16930146 @default.
- W2011946110 hasConcept C204232928 @default.
- W2011946110 hasConcept C2776235491 @default.
- W2011946110 hasConcept C2777562237 @default.
- W2011946110 hasConcept C2780192828 @default.
- W2011946110 hasConcept C502942594 @default.
- W2011946110 hasConcept C52124034 @default.
- W2011946110 hasConcept C71924100 @default.
- W2011946110 hasConcept C86803240 @default.
- W2011946110 hasConcept C87874733 @default.
- W2011946110 hasConceptScore W2011946110C118131993 @default.
- W2011946110 hasConceptScore W2011946110C121608353 @default.
- W2011946110 hasConceptScore W2011946110C126322002 @default.
- W2011946110 hasConceptScore W2011946110C142724271 @default.
- W2011946110 hasConceptScore W2011946110C16930146 @default.
- W2011946110 hasConceptScore W2011946110C204232928 @default.
- W2011946110 hasConceptScore W2011946110C2776235491 @default.
- W2011946110 hasConceptScore W2011946110C2777562237 @default.
- W2011946110 hasConceptScore W2011946110C2780192828 @default.
- W2011946110 hasConceptScore W2011946110C502942594 @default.
- W2011946110 hasConceptScore W2011946110C52124034 @default.
- W2011946110 hasConceptScore W2011946110C71924100 @default.
- W2011946110 hasConceptScore W2011946110C86803240 @default.
- W2011946110 hasConceptScore W2011946110C87874733 @default.
- W2011946110 hasIssue "S16H" @default.
- W2011946110 hasLocation W20119461101 @default.
- W2011946110 hasLocation W20119461102 @default.
- W2011946110 hasOpenAccess W2011946110 @default.
- W2011946110 hasPrimaryLocation W20119461101 @default.