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- W2011953956 abstract "Dysbindin-1 regulates D2-receptor trafficking and is implicated in schizophrenia and related cognitive abnormalities, but whether this molecular effect mediates the clinical manifestations of the disorder is unknown. We explored in dysbindin-1-deficient mice (dys−/−) (1) schizophrenia-related behaviors, (2) molecular and electrophysiological changes in medial prefrontal cortex (mPFC) and (3) the dependence of these on D2-receptor stimulation. Dysbindin-1 disruption altered dopamine-related behaviors and impaired working memory under challenging/stressful conditions. Dys−/− pyramidal neurons in mPFC layers II/III were hyperexcitable at baseline but hypoexcitable following D2 stimulation. Dys−/− were also respectively more and less sensitive to D2 agonist- and antagonist-induced behavioral effects. Dys−/− had reduced expression of Ca2+/calmodulin-dependent protein kinase II (CaMKII) and CaMKKβ in mPFC. Chronic D2 agonist treatment reproduced these changes in protein expression, and some of the dys−/− behavioral effects. These results elucidate dysbindin's modulation of D2-related behavior, cortical activity and mPFC CaMK components, implicating cellular and molecular mechanisms of the association of dysbindin with psychosis." @default.
- W2011953956 created "2016-06-24" @default.
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- W2011953956 date "2010-10-19" @default.
- W2011953956 modified "2023-10-15" @default.
- W2011953956 title "Dysbindin-1 modulates prefrontal cortical activity and schizophrenia-like behaviors via dopamine/D2 pathways" @default.
- W2011953956 cites W1512252703 @default.
- W2011953956 cites W1527753734 @default.
- W2011953956 cites W1535268439 @default.
- W2011953956 cites W1540290822 @default.
- W2011953956 cites W1602481380 @default.
- W2011953956 cites W1819218275 @default.
- W2011953956 cites W1952592959 @default.
- W2011953956 cites W1965267837 @default.
- W2011953956 cites W1966447861 @default.
- W2011953956 cites W1973371295 @default.
- W2011953956 cites W1975599306 @default.
- W2011953956 cites W1981768163 @default.
- W2011953956 cites W1982399538 @default.
- W2011953956 cites W1983566798 @default.
- W2011953956 cites W1984515516 @default.
- W2011953956 cites W1990217730 @default.
- W2011953956 cites W1994593489 @default.
- W2011953956 cites W1999528494 @default.
- W2011953956 cites W2002132239 @default.
- W2011953956 cites W2010166359 @default.
- W2011953956 cites W2015701831 @default.
- W2011953956 cites W2027691566 @default.
- W2011953956 cites W2029054478 @default.
- W2011953956 cites W2029059267 @default.
- W2011953956 cites W2032496811 @default.
- W2011953956 cites W2033294541 @default.
- W2011953956 cites W2038837541 @default.
- W2011953956 cites W2041457323 @default.
- W2011953956 cites W2042325100 @default.
- W2011953956 cites W2043321552 @default.
- W2011953956 cites W2046835548 @default.
- W2011953956 cites W2048148249 @default.
- W2011953956 cites W2050081796 @default.
- W2011953956 cites W2056357051 @default.
- W2011953956 cites W2057749702 @default.
- W2011953956 cites W2059669521 @default.
- W2011953956 cites W2063709171 @default.
- W2011953956 cites W2064396596 @default.
- W2011953956 cites W2073695504 @default.
- W2011953956 cites W2074795674 @default.
- W2011953956 cites W2076020270 @default.
- W2011953956 cites W2076347107 @default.
- W2011953956 cites W2077924634 @default.
- W2011953956 cites W2084395458 @default.
- W2011953956 cites W2090275517 @default.
- W2011953956 cites W2090979638 @default.
- W2011953956 cites W2093411259 @default.
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- W2011953956 cites W2102001229 @default.
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- W2011953956 cites W2112655025 @default.
- W2011953956 cites W2116888010 @default.
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- W2011953956 cites W2163563093 @default.
- W2011953956 cites W2165163501 @default.
- W2011953956 cites W2165294134 @default.
- W2011953956 cites W2165324329 @default.
- W2011953956 cites W2170259615 @default.
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- W2011953956 doi "https://doi.org/10.1038/mp.2010.106" @default.
- W2011953956 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3388848" @default.
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