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• W2011957079 endingPage "527" @default.
• W2011957079 startingPage "515" @default.
• W2011957079 abstract "Axonal growth from cortically placed fetal neural transplants to subcortical targets in adult hosts has been difficult to demonstrate and is assumed to be minimal; however, experiments using xenogeneic neural grafts of either human or porcine fetal tissues into the adult rat striatum, mesencephalon, and spinal cord have demonstrated the capability for long-distance axonal growth. This study reports similar results for porcine cortical xenografts placed in the adult rat cerebral cortex and compares these findings with results from cortical allografts. Adult rats that previously received unilateral cortical lesions by an oblique intracortical stereotaxic injection of quinolinic acid, were implanted with suspensions of either E14 rat or E38 xenogeneic porcine fetal cortical cells. Xenografted rats were immunosuppressed by cyclosporin A. The corpus callosum was intact in all cases and grafts were confined to the overlying cortex. After a 31–34 wk posttransplant survival period, acetylcholinesterase (AChE) staining and tyrosine hydroxylase (TH) immunocytochemistry revealed that both allo- and xenografts received host afferents. Retrograde tracer injections into the ipsilateral striatum and cerebral peduncle in allografted animals failed to show any axonal growth to either subcortical target. Using a porcine-specific axonal marker in xenografted animals, we found graft axons in white matter tracts (corpus callosum, internal capsule, cingulum bundle, and medial forebrain bundle) and within the caudate-putamen and both the ipsilateral and contralateral cerebral cortex. Graft axons were not found in the thalamus, midbrain, or spinal cord. In addition, using an antibody to porcine glial fibers, we observed more extensive graft glial fiber growth into the same host fiber tracts, as far caudally as the cerebral peduncle, but not into gray matter targets outside the cortex. These results demonstrate that porcine cortical xenograft axons and glia can extend from lesioned cerebral cortex to cortical and subcortical targets in the adult rat brain. These findings are relevant for prospects of repairing cortical damage and obtaining functional recovery." @default.
• W2011957079 created "2016-06-24" @default.
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• W2011957079 date "1995-10-01" @default.
• W2011957079 modified "2023-09-23" @default.
• W2011957079 title "Extensive axonal and glial fiber growth from fetal porcine cortical xenografts in the adult rat cortex" @default.
• W2011957079 cites W1179620735 @default.
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• W2011957079 cites W1565947331 @default.
• W2011957079 cites W1703876792 @default.
• W2011957079 cites W1843854943 @default.
• W2011957079 cites W1877556519 @default.
• W2011957079 cites W1899999601 @default.
• W2011957079 cites W1964616203 @default.
• W2011957079 cites W1967514485 @default.
• W2011957079 cites W1969165581 @default.
• W2011957079 cites W1971304382 @default.
• W2011957079 cites W1972608064 @default.
• W2011957079 cites W1975595527 @default.
• W2011957079 cites W1976452550 @default.
• W2011957079 cites W1982533391 @default.
• W2011957079 cites W1986598942 @default.
• W2011957079 cites W1988582833 @default.
• W2011957079 cites W1988958353 @default.
• W2011957079 cites W1993193182 @default.
• W2011957079 cites W1993724129 @default.
• W2011957079 cites W2000043495 @default.
• W2011957079 cites W2000391017 @default.
• W2011957079 cites W2006135298 @default.
• W2011957079 cites W2007435487 @default.
• W2011957079 cites W2008320280 @default.
• W2011957079 cites W2013293997 @default.
• W2011957079 cites W2013968703 @default.
• W2011957079 cites W2014682180 @default.
• W2011957079 cites W2016032905 @default.
• W2011957079 cites W2016293448 @default.
• W2011957079 cites W2020669159 @default.
• W2011957079 cites W2021346586 @default.
• W2011957079 cites W2022274052 @default.
• W2011957079 cites W2022769757 @default.
• W2011957079 cites W2023172568 @default.
• W2011957079 cites W2027126363 @default.
• W2011957079 cites W2027424990 @default.
• W2011957079 cites W2029677656 @default.
• W2011957079 cites W2029768920 @default.
• W2011957079 cites W2031525523 @default.
• W2011957079 cites W2032585771 @default.
• W2011957079 cites W2033850774 @default.
• W2011957079 cites W2034193760 @default.
• W2011957079 cites W2036564942 @default.
• W2011957079 cites W2042550512 @default.
• W2011957079 cites W2043301339 @default.
• W2011957079 cites W2045662389 @default.
• W2011957079 cites W2050415048 @default.
• W2011957079 cites W2051353156 @default.
• W2011957079 cites W2057459600 @default.
• W2011957079 cites W2059287299 @default.
• W2011957079 cites W2063778865 @default.
• W2011957079 cites W2069939577 @default.
• W2011957079 cites W2072229950 @default.
• W2011957079 cites W2075312842 @default.
• W2011957079 cites W2080464961 @default.
• W2011957079 cites W2081028995 @default.
• W2011957079 cites W2083822221 @default.
• W2011957079 cites W2083986625 @default.
• W2011957079 cites W2085287004 @default.
• W2011957079 cites W2087091643 @default.
• W2011957079 cites W2089984224 @default.
• W2011957079 cites W2095324434 @default.
• W2011957079 cites W2096763981 @default.
• W2011957079 cites W2097530133 @default.
• W2011957079 cites W2098881993 @default.
• W2011957079 cites W2108758429 @default.
• W2011957079 cites W2116181102 @default.
• W2011957079 cites W2128216834 @default.
• W2011957079 cites W2135781323 @default.
• W2011957079 cites W2163708115 @default.
• W2011957079 cites W3162876745 @default.
• W2011957079 cites W3215981791 @default.
• W2011957079 cites W563232987 @default.
• W2011957079 cites W578476645 @default.
• W2011957079 cites W950607055 @default.
• W2011957079 doi "https://doi.org/10.1016/0963-6897(95)00027-u" @default.
• W2011957079 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8520835" @default.
• W2011957079 hasPublicationYear "1995" @default.
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