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- W2011964668 abstract "Prolonged high-dose administration of estrogens in middle-aged men with coronary heart disease resulted in persistent lowering of total serum cholesterol, CP and βga ratios. Normal thyroid function was maintained, despite some decrease in the 24-hr 131I uptake in a small group in whom such studies were done. 17-Ketosteroid fractions of exclusively adrenal origin were unchanged, whereas androsterone and etiocholanolone decreased by about 40 per cent. Most of the patients (63.1 per cent) tolerated long-term estrogen therapy but there were significant side-effects, including breast hypertrophy and testicular atrophy accompanied by loss of sex function. Serious side-effects such as water retention and depressive reaction requiring the omission of the drug, occurred in 10 of the 57 patients." @default.
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- W2011964668 date "1963-02-01" @default.
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- W2011964668 title "Long-term effects of high-dosage estrogen therapy in men with coronary heart disease" @default.
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- W2011964668 doi "https://doi.org/10.1016/0021-9681(63)90092-4" @default.
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