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• W2011965964 abstract "Sphingosine is sphingomyelin metabolite which has been shown to play an important role in such fundamental biological processes as cell proliferation, differentiation, and oncogenesis [1]. Sphingolipids may be involved in cell signaling via agonist-induced activation of sphingomyelin cycle which results in the generation of ceramide, sphingosine, and other sphingolipid metabolites. The activation of this pathway has been implicated in signal transduction processes associated with specific agonists. Sphingosine has been also shown to inhibit protein kinase C [2]and modulate activity of other biochemical targets in vitro; i) it inhibits calmodulin-dependent enzymes [3], phosphatidate phosphohydrolase [4], and binding of factor VII to tissue factor [5], ii) it activates epidermal growth factor receptor kinase [6]and phospholipase D [7], iii) it exerts mitogenic effects on Swiss 3T3 cells at low concentrations [8]." @default.
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• W2011965964 date "1997-08-01" @default.
• W2011965964 modified "2023-10-14" @default.
• W2011965964 title "SPHINGOSINE STIMULATES THROMBIN-INDUCED GELATION OF THE FIBRINOGEN" @default.
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• W2011965964 doi "https://doi.org/10.1016/s0049-3848(97)00135-7" @default.
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