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• W2011966388 abstract "□ American trypanosomiasis (Chagas’ disease) is an endemic parasitic disease afflicting more than 20 million people in Latin America. Currently , therapy is unsatisfactory and only two drugs are available. Primaquine, an antimalarial drug, has trypanocidal activity. Dipeptide derivatives of primaquine, Phe-Arg-PQ, Lys-Arg-PQ, and Phe-Ala-PQ, were synthesized. The choice of the peptides was based on the primary specificity of cruzipain, the major cysteine proteinase from T cruzi. The prodrugs obtained were tested on the LLC-MK2 cell culture infected with trypomastigotes forms of T. cruzi Phe-Arg-PQ, Lys-Arg-PQ, and Phe-Ala-PQ were active in all stages." @default.
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• W2011966388 date "1997-10-01" @default.
• W2011966388 modified "2023-10-02" @default.
• W2011966388 title "Synthesis and in Vitro Evaluation of Potential Antichagasic Dipeptide Prodrugs of Primaquine" @default.
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• W2011966388 doi "https://doi.org/10.1021/js970006v" @default.
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