FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011969560> ?p ?o ?g. }

• W2011969560 endingPage "359" @default.
• W2011969560 startingPage "356" @default.
• W2011969560 abstract "Abstract Objective Clinical evidence and experimental evidence suggest that anti‐Ro/La autoantibodies are necessary but not sufficient for the development of congenital complete heart block (CCHB). Maternal, fetal, and environmental factors may also contribute to heart damage in CCHB. The aim of our study was to investigate polymorphisms of transforming growth factor β1 (TGFβ1) and tumor necrosis factor α (TNFα) genes in twins and triplets discordant for CCHB whose mothers are anti‐Ro/La positive. Methods We studied 2 families in which 1 of the mothers gave birth to triplets and the other gave birth to twins. Only 1 child in each family was affected by CCHB, although 1 of the triplets had incomplete heart block. We analyzed TNFα and TGFβ1 polymorphisms in the 2 babies with CCHB and their siblings. TNFα polymorphisms at the promoter region and TGFβ1 polymorphisms at codons 10 and 25 were determined using polymerase chain reaction–restriction fragment length polymorphism analysis. In addition, the production of TGFβ1 and TNFα by resting or mitogen‐stimulated peripheral blood mononuclear cells in cell culture supernatants was evaluated by enzyme‐linked immunosorbent assay. Results The profibrotic TGFβ1 genotype was detected in the twin with CCHB but not in the healthy twin, while all of the triplets displayed the same TGFβ1 genotype at codon 10. Peripheral blood mononuclear cells from the children with CCHB displayed higher spontaneous and mitogen‐stimulated TGFβ1 secretion than was observed in their siblings. No differences regarding TNFα polymorphisms and secretion of TNFα were observed. Conclusion The results of this study suggest that, besides anti‐Ro/La autoantibodies, a fetal profibrotic response might contribute to the development of CCHB, but additional pathogenic mechanism(s) are also likely to play a role." @default.
• W2011969560 created "2016-06-24" @default.
• W2011969560 creator A5016712530 @default.
• W2011969560 creator A5025603447 @default.
• W2011969560 creator A5030466896 @default.
• W2011969560 creator A5063656963 @default.
• W2011969560 creator A5075020183 @default.
• W2011969560 creator A5075394900 @default.
• W2011969560 date "2005-12-29" @default.
• W2011969560 modified "2023-10-11" @default.
• W2011969560 title "Transforming growth factor β1 in the pathogenesis of autoimmune congenital complete heart block: Lesson from twins and triplets discordant for the disease" @default.
• W2011969560 cites W1955584766 @default.
• W2011969560 cites W1983933275 @default.
• W2011969560 cites W2034508361 @default.
• W2011969560 cites W2050203849 @default.
• W2011969560 cites W2072104006 @default.
• W2011969560 cites W2074960079 @default.
• W2011969560 cites W2080285185 @default.
• W2011969560 cites W2095906365 @default.
• W2011969560 cites W2142789904 @default.
• W2011969560 cites W2153031655 @default.
• W2011969560 cites W2166266976 @default.
• W2011969560 cites W2409250692 @default.
• W2011969560 cites W4319704929 @default.
• W2011969560 doi "https://doi.org/10.1002/art.21546" @default.
• W2011969560 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16385528" @default.
• W2011969560 hasPublicationYear "2005" @default.
• W2011969560 type Work @default.
• W2011969560 sameAs 2011969560 @default.
• W2011969560 citedByCount "25" @default.
• W2011969560 countsByYear W20119695602013 @default.
• W2011969560 countsByYear W20119695602014 @default.
• W2011969560 countsByYear W20119695602015 @default.
• W2011969560 countsByYear W20119695602016 @default.
• W2011969560 countsByYear W20119695602017 @default.
• W2011969560 countsByYear W20119695602019 @default.
• W2011969560 countsByYear W20119695602021 @default.
• W2011969560 crossrefType "journal-article" @default.
• W2011969560 hasAuthorship W2011969560A5016712530 @default.
• W2011969560 hasAuthorship W2011969560A5025603447 @default.
• W2011969560 hasAuthorship W2011969560A5030466896 @default.
• W2011969560 hasAuthorship W2011969560A5063656963 @default.
• W2011969560 hasAuthorship W2011969560A5075020183 @default.
• W2011969560 hasAuthorship W2011969560A5075394900 @default.
• W2011969560 hasBestOaLocation W20119695601 @default.
• W2011969560 hasConcept C104317684 @default.
• W2011969560 hasConcept C118131993 @default.
• W2011969560 hasConcept C126322002 @default.
• W2011969560 hasConcept C134018914 @default.
• W2011969560 hasConcept C135763542 @default.
• W2011969560 hasConcept C137061746 @default.
• W2011969560 hasConcept C159654299 @default.
• W2011969560 hasConcept C163764329 @default.
• W2011969560 hasConcept C17991360 @default.
• W2011969560 hasConcept C202751555 @default.
• W2011969560 hasConcept C203014093 @default.
• W2011969560 hasConcept C2780942790 @default.
• W2011969560 hasConcept C54355233 @default.
• W2011969560 hasConcept C71924100 @default.
• W2011969560 hasConcept C86803240 @default.
• W2011969560 hasConceptScore W2011969560C104317684 @default.
• W2011969560 hasConceptScore W2011969560C118131993 @default.
• W2011969560 hasConceptScore W2011969560C126322002 @default.
• W2011969560 hasConceptScore W2011969560C134018914 @default.
• W2011969560 hasConceptScore W2011969560C135763542 @default.
• W2011969560 hasConceptScore W2011969560C137061746 @default.
• W2011969560 hasConceptScore W2011969560C159654299 @default.
• W2011969560 hasConceptScore W2011969560C163764329 @default.
• W2011969560 hasConceptScore W2011969560C17991360 @default.
• W2011969560 hasConceptScore W2011969560C202751555 @default.
• W2011969560 hasConceptScore W2011969560C203014093 @default.
• W2011969560 hasConceptScore W2011969560C2780942790 @default.
• W2011969560 hasConceptScore W2011969560C54355233 @default.
• W2011969560 hasConceptScore W2011969560C71924100 @default.
• W2011969560 hasConceptScore W2011969560C86803240 @default.
• W2011969560 hasIssue "1" @default.
• W2011969560 hasLocation W20119695601 @default.
• W2011969560 hasLocation W20119695602 @default.
• W2011969560 hasLocation W20119695603 @default.
• W2011969560 hasOpenAccess W2011969560 @default.
• W2011969560 hasPrimaryLocation W20119695601 @default.
• W2011969560 hasRelatedWork W2037368117 @default.
• W2011969560 hasRelatedWork W2365906682 @default.
• W2011969560 hasRelatedWork W2368747855 @default.
• W2011969560 hasRelatedWork W2371407351 @default.
• W2011969560 hasRelatedWork W2392753015 @default.
• W2011969560 hasRelatedWork W2394478663 @default.
• W2011969560 hasRelatedWork W2604923520 @default.
• W2011969560 hasRelatedWork W2784784403 @default.
• W2011969560 hasRelatedWork W4290546638 @default.
• W2011969560 hasRelatedWork W3031535749 @default.
• W2011969560 hasVolume "54" @default.
• W2011969560 isParatext "false" @default.
• W2011969560 isRetracted "false" @default.
• W2011969560 magId "2011969560" @default.
• W2011969560 workType "article" @default.