Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011977440> ?p ?o ?g. }
- W2011977440 endingPage "818" @default.
- W2011977440 startingPage "808" @default.
- W2011977440 abstract "Summary Pre‐transplant conditioning regimens play a major role in triggering graft‐versus‐host disease ( GVHD ). This study investigated the effect of irradiation on donor T cell trafficking to lymphoid and non‐lymphoid tissues by comparing the migration of carboxy‐fluorescein diacetate succinimidyl ester‐labelled, naïve donor T lymphocytes in vivo in irradiated and non‐irradiated syngeneic mice recipients. Recruitment of adoptively transferred naïve T cells to secondary lymphoid organs was increased in irradiated mice and naïve T cells also aberrantly localized to non‐lymphoid tissues. Irradiation also induced aberrant effector memory T cell migration into lymph nodes and their localization to homing‐privileged non‐lymphoid sites, such as the gut. The presence of a minor histocompatibility mismatch further enhanced the aberrant accumulation of T cells in both lymphoid and non‐lymphoid tissue, whilst their migratory pattern was not modified as compared to fully matched irradiated recipients. These effects correlated with decreased permeability of, and the secretion of chemotactic factors by the endothelium. Our findings are consistent with the possibility that excessive, dysregulated extravasation of T cells induced by irradiation promotes the development of GVHD ." @default.
- W2011977440 created "2016-06-24" @default.
- W2011977440 creator A5009574264 @default.
- W2011977440 creator A5012703542 @default.
- W2011977440 creator A5026172020 @default.
- W2011977440 creator A5051999950 @default.
- W2011977440 creator A5055126724 @default.
- W2011977440 creator A5061733081 @default.
- W2011977440 creator A5062284019 @default.
- W2011977440 date "2013-07-15" @default.
- W2011977440 modified "2023-10-04" @default.
- W2011977440 title "Enhanced and aberrant T cell trafficking following total body irradiation: a gateway to graft-versus-host disease?" @default.
- W2011977440 cites W124910842 @default.
- W2011977440 cites W1508586454 @default.
- W2011977440 cites W1521515468 @default.
- W2011977440 cites W1562712212 @default.
- W2011977440 cites W1591316404 @default.
- W2011977440 cites W1602835962 @default.
- W2011977440 cites W1610017743 @default.
- W2011977440 cites W1946381923 @default.
- W2011977440 cites W1950204667 @default.
- W2011977440 cites W1969756923 @default.
- W2011977440 cites W1976161748 @default.
- W2011977440 cites W1981480494 @default.
- W2011977440 cites W1983524381 @default.
- W2011977440 cites W1988620205 @default.
- W2011977440 cites W1988718803 @default.
- W2011977440 cites W1990046941 @default.
- W2011977440 cites W2002505144 @default.
- W2011977440 cites W2011277680 @default.
- W2011977440 cites W2012583597 @default.
- W2011977440 cites W2013366468 @default.
- W2011977440 cites W2021425288 @default.
- W2011977440 cites W2034952320 @default.
- W2011977440 cites W2042626190 @default.
- W2011977440 cites W2042980141 @default.
- W2011977440 cites W2050659130 @default.
- W2011977440 cites W2057602456 @default.
- W2011977440 cites W2058582950 @default.
- W2011977440 cites W2064990682 @default.
- W2011977440 cites W2067564880 @default.
- W2011977440 cites W2068699102 @default.
- W2011977440 cites W2075369772 @default.
- W2011977440 cites W2081097093 @default.
- W2011977440 cites W2081596482 @default.
- W2011977440 cites W2085530853 @default.
- W2011977440 cites W2090667771 @default.
- W2011977440 cites W2125650988 @default.
- W2011977440 cites W2149277015 @default.
- W2011977440 cites W2159433435 @default.
- W2011977440 cites W2159506479 @default.
- W2011977440 cites W2279252100 @default.
- W2011977440 cites W2287087682 @default.
- W2011977440 cites W2317145780 @default.
- W2011977440 cites W2443505819 @default.
- W2011977440 doi "https://doi.org/10.1111/bjh.12472" @default.
- W2011977440 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23855835" @default.
- W2011977440 hasPublicationYear "2013" @default.
- W2011977440 type Work @default.
- W2011977440 sameAs 2011977440 @default.
- W2011977440 citedByCount "7" @default.
- W2011977440 countsByYear W20119774402015 @default.
- W2011977440 countsByYear W20119774402016 @default.
- W2011977440 countsByYear W20119774402017 @default.
- W2011977440 countsByYear W20119774402018 @default.
- W2011977440 countsByYear W20119774402021 @default.
- W2011977440 countsByYear W20119774402022 @default.
- W2011977440 crossrefType "journal-article" @default.
- W2011977440 hasAuthorship W2011977440A5009574264 @default.
- W2011977440 hasAuthorship W2011977440A5012703542 @default.
- W2011977440 hasAuthorship W2011977440A5026172020 @default.
- W2011977440 hasAuthorship W2011977440A5051999950 @default.
- W2011977440 hasAuthorship W2011977440A5055126724 @default.
- W2011977440 hasAuthorship W2011977440A5061733081 @default.
- W2011977440 hasAuthorship W2011977440A5062284019 @default.
- W2011977440 hasBestOaLocation W20119774401 @default.
- W2011977440 hasConcept C109159458 @default.
- W2011977440 hasConcept C142724271 @default.
- W2011977440 hasConcept C151872237 @default.
- W2011977440 hasConcept C181152851 @default.
- W2011977440 hasConcept C18903297 @default.
- W2011977440 hasConcept C203014093 @default.
- W2011977440 hasConcept C2776090121 @default.
- W2011977440 hasConcept C2779972918 @default.
- W2011977440 hasConcept C28328180 @default.
- W2011977440 hasConcept C71924100 @default.
- W2011977440 hasConcept C79904392 @default.
- W2011977440 hasConcept C86803240 @default.
- W2011977440 hasConcept C8891405 @default.
- W2011977440 hasConcept C95444343 @default.
- W2011977440 hasConceptScore W2011977440C109159458 @default.
- W2011977440 hasConceptScore W2011977440C142724271 @default.
- W2011977440 hasConceptScore W2011977440C151872237 @default.
- W2011977440 hasConceptScore W2011977440C181152851 @default.
- W2011977440 hasConceptScore W2011977440C18903297 @default.
- W2011977440 hasConceptScore W2011977440C203014093 @default.
- W2011977440 hasConceptScore W2011977440C2776090121 @default.
- W2011977440 hasConceptScore W2011977440C2779972918 @default.