FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011991330> ?p ?o ?g. }

• W2011991330 endingPage "870" @default.
• W2011991330 startingPage "855" @default.
• W2011991330 abstract "Previous studies from this and other laboratories demonstrated that many embryonic sensory ganglion cells in the rat transiently express the catecholamine synthesizing enzyme tyrosine hydroxylase (TH), a trait not expressed by most mature sensory neurons. We, therefore, sought to determine whether transient expression was uniquely associated with catecholaminergic traits, or, alternatively, whether embryonic ganglion cells transiently expressed peptidergic properties as well. Of the four peptides examined (somatostatin [somatotropin release inhibiting factor] (SRIF), galanin (Gal), calcitonin gene-related peptide (CGRP), and substance P (SP)), only SRIF was found to be transiently expressed during early stages of sensory gangliogenesis. Surprisingly, SRIF immunoreactivity was observed in virtually all cranial and spinal sensory ganglion cells on embryonic day (E) 12.5. In addition to perikaryal labeling, intense SRIF immunoreactivity was also observed in the central and peripheral processes of E12.5 sensory neurons, suggesting the peptide may be released from nerve endings. The time course of SRIF appearance in cranial ganglion cells paralleled that previously described for TH, and double-labeling studies revealed extensive co-localization of these two phenotypes. By E16.5, however, the number of neurons expressing SRIF had diminished markedly, indicating that SRIF is only transiently expressed by most sensory neurons during early stages of ganglion development. An unexpected finding was that transient expression of SRIF is also a prominent feature of sympathetic ganglion cells; however, the temporal pattern of staining in the sympathetic and sensory ganglia differed substantially. Whereas virtually no SRIF staining was observed in E12.5 sympathetics, the vast majority of cells in the E16.5 superior cervical ganglion (SCG) were labeled. This contrasted sharply with the adult SCG, in which only low levels of SRIF expression were found. These findings demonstrate that SRIF peptide is transiently expressed at high levels in peripheral sensory and sympathetic neurons during embryogenesis. The time course and widespread distribution of SRIF expression indicates that the peptide may play a role in early stages of ganglion cell growth and development. Moreover, these data, in conjunction with previous studies demonstrating SRIF immunoreactivity in developing central neurons, suggest that transient expression of this peptide is a common property of diverse neuronal cell types." @default.
• W2011991330 created "2016-06-24" @default.
• W2011991330 creator A5027428880 @default.
• W2011991330 creator A5039063713 @default.
• W2011991330 creator A5054414118 @default.
• W2011991330 date "1992-09-01" @default.
• W2011991330 modified "2023-09-25" @default.
• W2011991330 title "Transient expression of somatostatin peptide is a widespread feature of developing sensory and sympathetic neurons in the embryonic rat" @default.
• W2011991330 cites W1493164359 @default.
• W2011991330 cites W1591414872 @default.
• W2011991330 cites W1914197820 @default.
• W2011991330 cites W1919036270 @default.
• W2011991330 cites W1964454007 @default.
• W2011991330 cites W1966826692 @default.
• W2011991330 cites W1968969894 @default.
• W2011991330 cites W1969222610 @default.
• W2011991330 cites W1974741752 @default.
• W2011991330 cites W1974749992 @default.
• W2011991330 cites W1977711719 @default.
• W2011991330 cites W1982246065 @default.
• W2011991330 cites W1984834458 @default.
• W2011991330 cites W1986989004 @default.
• W2011991330 cites W1992079422 @default.
• W2011991330 cites W1995760096 @default.
• W2011991330 cites W2000614632 @default.
• W2011991330 cites W2002946255 @default.
• W2011991330 cites W2004588609 @default.
• W2011991330 cites W2004811970 @default.
• W2011991330 cites W2007052443 @default.
• W2011991330 cites W2008136969 @default.
• W2011991330 cites W2012844837 @default.
• W2011991330 cites W2014118046 @default.
• W2011991330 cites W2014339903 @default.
• W2011991330 cites W2017671038 @default.
• W2011991330 cites W2026942725 @default.
• W2011991330 cites W2034379792 @default.
• W2011991330 cites W2035343834 @default.
• W2011991330 cites W2036429088 @default.
• W2011991330 cites W2037444784 @default.
• W2011991330 cites W2040471409 @default.
• W2011991330 cites W2041827288 @default.
• W2011991330 cites W2043208977 @default.
• W2011991330 cites W2044734184 @default.
• W2011991330 cites W2047938839 @default.
• W2011991330 cites W2050739562 @default.
• W2011991330 cites W2050872725 @default.
• W2011991330 cites W2052810218 @default.
• W2011991330 cites W2054244155 @default.
• W2011991330 cites W2054956674 @default.
• W2011991330 cites W2056955251 @default.
• W2011991330 cites W2058543880 @default.
• W2011991330 cites W2067475968 @default.
• W2011991330 cites W2068290015 @default.
• W2011991330 cites W2071185127 @default.
• W2011991330 cites W2076279547 @default.
• W2011991330 cites W2080736942 @default.
• W2011991330 cites W2080943726 @default.
• W2011991330 cites W2081625123 @default.
• W2011991330 cites W2082996866 @default.
• W2011991330 cites W2086227547 @default.
• W2011991330 cites W2088078672 @default.
• W2011991330 cites W2088712569 @default.
• W2011991330 cites W2089099952 @default.
• W2011991330 cites W2094858627 @default.
• W2011991330 cites W2126707217 @default.
• W2011991330 cites W2146119530 @default.
• W2011991330 cites W2177396885 @default.
• W2011991330 cites W2277063536 @default.
• W2011991330 cites W2329575852 @default.
• W2011991330 cites W2335897665 @default.
• W2011991330 cites W2426721015 @default.
• W2011991330 cites W4230527272 @default.
• W2011991330 cites W4299366254 @default.
• W2011991330 cites W4301042381 @default.
• W2011991330 doi "https://doi.org/10.1002/neu.480230707" @default.
• W2011991330 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1359005" @default.
• W2011991330 hasPublicationYear "1992" @default.
• W2011991330 type Work @default.
• W2011991330 sameAs 2011991330 @default.
• W2011991330 citedByCount "27" @default.
• W2011991330 countsByYear W20119913302022 @default.
• W2011991330 crossrefType "journal-article" @default.
• W2011991330 hasAuthorship W2011991330A5027428880 @default.
• W2011991330 hasAuthorship W2011991330A5039063713 @default.
• W2011991330 hasAuthorship W2011991330A5054414118 @default.
• W2011991330 hasConcept C104317684 @default.
• W2011991330 hasConcept C118303440 @default.
• W2011991330 hasConcept C126322002 @default.
• W2011991330 hasConcept C134018914 @default.
• W2011991330 hasConcept C145103041 @default.
• W2011991330 hasConcept C159167319 @default.
• W2011991330 hasConcept C163170386 @default.
• W2011991330 hasConcept C169760540 @default.
• W2011991330 hasConcept C170493617 @default.
• W2011991330 hasConcept C19519825 @default.
• W2011991330 hasConcept C2775894120 @default.
• W2011991330 hasConcept C2775908076 @default.
• W2011991330 hasConcept C2776297358 @default.

• next