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- W2011992403 abstract "The use of saliva chloroquine concentrations measurement as a noninvasive technique in the evaluation of the pharmacokinetics of the drug was investigated. Chloroquine concentrations in saliva and plasma were measured in eight healthy volunteers after a single oral dose of two tablets of chloroquine sulfate. The saliva:total plasma concentrations (S/P) ratio was found to be approximately constant in the absorption (0.4 ± 0.07), distribution (0.47 ± 0.08), and elimination (0.46 ± 0.05) phases. Thus, saliva sampling for chloroquine concentrations was found to be a useful noninvasive technique for the estimation of all the pharmacokinetic parameters of the drug and hence, for chloroquine pharmacokinetic studies." @default.
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- W2011992403 date "1989-12-01" @default.
- W2011992403 modified "2023-10-18" @default.
- W2011992403 title "Determination of Saliva: Total Plasma Chloroquine Levels Relationship by High Performance Liquid Chromatography" @default.
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- W2011992403 doi "https://doi.org/10.1002/j.1552-4604.1989.tb03291.x" @default.
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