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• W2011994814 abstract "Mutations in transcription factor 4 (TCF4) have recently been described in myeloid dysplastic syndromes (MDS) and acute myeloid leukemia (AML). We analyzed the impact of TCF4 mRNA expression on clinical outcome in AML patients (n=525). Patients with high TCF4 expression (TCF4high, defined as the 25% highest TCF4 expressors) had a significantly worse overall survival (OS) and event-free survival (EFS) than patients with lower TCF4 expression (TCF4low) (5-year OS 18% vs. 44%, P<0.0001; 5-year EFS 15% vs. 34%, P<0.0001, respectively). This was confirmed in an independent cohort (n=436). Multivariate analysis showed that TCF4high is an independent prognostic factor for OS and EFS in the whole cohort and in patients carrying a normal karyotype." @default.
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• W2011994814 date "2014-08-22" @default.
• W2011994814 modified "2023-09-30" @default.
• W2011994814 title "High expression of transcription factor 4 (TCF4) is an independent adverse prognostic factor in acute myeloid leukemia that could guide treatment decisions" @default.
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• W2011994814 doi "https://doi.org/10.3324/haematol.2014.110437" @default.
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