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- W2011997519 endingPage "69" @default.
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- W2011997519 abstract "Studies have established hyperglycemia as the most important factor in the progress of vascular complications. Formation of advanced glycation end products (AGEs) correlates with glycemic control. The AGE hypothesis proposes that hyperglycemia contributes to the pathogenesis of diabetic complications including retinopathy. However, their role in diabetic retinopathy remains largely unknown. This review discusses the chemistry of AGEs formation and their patho-biochemistry particularly in relation to diabetic retinopathy. AGEs exert deleterious effects by acting directly to induce cross-linking of long-lived proteins to promote vascular stiffness, altering vascular structure and function and interacting with receptor for AGE, to induce intracellular signaling leading to enhanced oxidative stress and elaboration of key proinflammatory and prosclerotic cytokines. Novel anti-AGE strategies are being developed hoping that in next few years, some of these promising therapies will be successfully evaluated in clinical context aiming to reduce the major economical and medical burden caused by diabetic retinopathy." @default.
- W2011997519 created "2016-06-24" @default.
- W2011997519 creator A5012595037 @default.
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- W2011997519 creator A5033505915 @default.
- W2011997519 creator A5043335082 @default.
- W2011997519 creator A5091100806 @default.
- W2011997519 date "2012-12-01" @default.
- W2011997519 modified "2023-09-23" @default.
- W2011997519 title "Advanced glycation end products and diabetic retinopathy" @default.
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