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- W2012003808 abstract "We have exploited a cross-species expression screen to search for cellular immortalizing activities. A newt blastemal cDNA expression library was transfected into rat embryo fibroblasts and immortal cell lines were selected. This identified a 1-kb cDNA fragment which has a low representation in the cDNA library and is derived from the 3′-UTR of an α-glucosidase-related mRNA. Expression of this sequence in rat embryo fibroblasts has shown that it is active in promoting colony formation and immortalization. It is also able to cooperate with an immortalization-defective deletion mutant of SV40 T antigen, indicating that it can exert its growth-stimulatory activity in the pathway activated by a viral immortalizing oncogene. This is the first example of an immortalizing activity mediated by an RNA sequence, and further analysis of its mechanism should provide new insights into senescence and immortalization." @default.
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- W2012003808 date "1998-05-01" @default.
- W2012003808 modified "2023-10-11" @default.
- W2012003808 title "Immortalization of Rat Embryo Fibroblasts by a 3′-Untranslated Region" @default.
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- W2012003808 doi "https://doi.org/10.1006/excr.1998.3937" @default.
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