FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012004265> ?p ?o ?g. }

• W2012004265 endingPage "3354" @default.
• W2012004265 startingPage "3346" @default.
• W2012004265 abstract "ABSTRACT Phosphopantetheinyl transferases (PPTases) are essential to the activities of type I/II polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs) through converting acyl carrier proteins (ACPs) in PKSs and peptidyl carrier proteins (PCPs) in NRPSs from inactive apo-forms into active holo-forms, leading to biosynthesis of polyketides and nonribosomal peptides. The industrial natamycin (NTM) producer, Streptomyces chattanoogensis L10, contains two PPTases (SchPPT and SchACPS) and five PKSs. Biochemical characterization of these two PPTases shows that SchPPT catalyzes the phosphopantetheinylation of ACPs in both type I PKSs and type II PKSs, SchACPS catalyzes the phosphopantetheinylation of ACPs in type II PKSs and fatty acid synthases (FASs), and the specificity of SchPPT is possibly controlled by its C terminus. Inactivation of SchPPT in S. chattanoogensis L10 abolished production of NTM but not the spore pigment, while overexpression of the SchPPT gene not only increased NTM production by about 40% but also accelerated productions of both NTM and the spore pigment. Thus, we elucidated a comprehensive phosphopantetheinylation network of PKSs and improved polyketide production by engineering the cognate PPTase in bacteria." @default.
• W2012004265 created "2016-06-24" @default.
• W2012004265 creator A5025330216 @default.
• W2012004265 creator A5034380945 @default.
• W2012004265 creator A5040978227 @default.
• W2012004265 creator A5042310477 @default.
• W2012004265 creator A5069777246 @default.
• W2012004265 creator A5070134243 @default.
• W2012004265 creator A5079817035 @default.
• W2012004265 date "2013-06-01" @default.
• W2012004265 modified "2023-10-17" @default.
• W2012004265 title "Improvement of Natamycin Production by Engineering of Phosphopantetheinyl Transferases in Streptomyces chattanoogensis L10" @default.
• W2012004265 cites W1591120304 @default.
• W2012004265 cites W1598992418 @default.
• W2012004265 cites W1818084123 @default.
• W2012004265 cites W1975610936 @default.
• W2012004265 cites W1984476760 @default.
• W2012004265 cites W2002641338 @default.
• W2012004265 cites W2003006345 @default.
• W2012004265 cites W2003107930 @default.
• W2012004265 cites W2006684372 @default.
• W2012004265 cites W2017271290 @default.
• W2012004265 cites W2018847934 @default.
• W2012004265 cites W2019724758 @default.
• W2012004265 cites W2023950913 @default.
• W2012004265 cites W2025073119 @default.
• W2012004265 cites W2026193159 @default.
• W2012004265 cites W2026570450 @default.
• W2012004265 cites W2028908252 @default.
• W2012004265 cites W2036080658 @default.
• W2012004265 cites W2036590099 @default.
• W2012004265 cites W2058438531 @default.
• W2012004265 cites W2096234478 @default.
• W2012004265 cites W2107595989 @default.
• W2012004265 cites W2107713423 @default.
• W2012004265 cites W2112177720 @default.
• W2012004265 cites W2114206141 @default.
• W2012004265 cites W2114895273 @default.
• W2012004265 cites W2126770666 @default.
• W2012004265 cites W2127667683 @default.
• W2012004265 cites W2128114769 @default.
• W2012004265 cites W2128429509 @default.
• W2012004265 cites W2133253129 @default.
• W2012004265 cites W2133790733 @default.
• W2012004265 cites W2134639528 @default.
• W2012004265 cites W2134814760 @default.
• W2012004265 cites W2153903162 @default.
• W2012004265 cites W2164899121 @default.
• W2012004265 cites W2170284392 @default.
• W2012004265 cites W4322384875 @default.
• W2012004265 doi "https://doi.org/10.1128/aem.00099-13" @default.
• W2012004265 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3648053" @default.
• W2012004265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23524668" @default.
• W2012004265 hasPublicationYear "2013" @default.
• W2012004265 type Work @default.
• W2012004265 sameAs 2012004265 @default.
• W2012004265 citedByCount "43" @default.
• W2012004265 countsByYear W20120042652014 @default.
• W2012004265 countsByYear W20120042652015 @default.
• W2012004265 countsByYear W20120042652016 @default.
• W2012004265 countsByYear W20120042652017 @default.
• W2012004265 countsByYear W20120042652018 @default.
• W2012004265 countsByYear W20120042652019 @default.
• W2012004265 countsByYear W20120042652020 @default.
• W2012004265 countsByYear W20120042652021 @default.
• W2012004265 countsByYear W20120042652022 @default.
• W2012004265 countsByYear W20120042652023 @default.
• W2012004265 crossrefType "journal-article" @default.
• W2012004265 hasAuthorship W2012004265A5025330216 @default.
• W2012004265 hasAuthorship W2012004265A5034380945 @default.
• W2012004265 hasAuthorship W2012004265A5040978227 @default.
• W2012004265 hasAuthorship W2012004265A5042310477 @default.
• W2012004265 hasAuthorship W2012004265A5069777246 @default.
• W2012004265 hasAuthorship W2012004265A5070134243 @default.
• W2012004265 hasAuthorship W2012004265A5079817035 @default.
• W2012004265 hasBestOaLocation W20120042651 @default.
• W2012004265 hasConcept C104317684 @default.
• W2012004265 hasConcept C124420848 @default.
• W2012004265 hasConcept C2777379556 @default.
• W2012004265 hasConcept C2777763344 @default.
• W2012004265 hasConcept C2778635478 @default.
• W2012004265 hasConcept C2779117757 @default.
• W2012004265 hasConcept C2779920670 @default.
• W2012004265 hasConcept C2780786045 @default.
• W2012004265 hasConcept C31903555 @default.
• W2012004265 hasConcept C523546767 @default.
• W2012004265 hasConcept C54355233 @default.
• W2012004265 hasConcept C553450214 @default.
• W2012004265 hasConcept C55493867 @default.
• W2012004265 hasConcept C86803240 @default.
• W2012004265 hasConceptScore W2012004265C104317684 @default.
• W2012004265 hasConceptScore W2012004265C124420848 @default.
• W2012004265 hasConceptScore W2012004265C2777379556 @default.
• W2012004265 hasConceptScore W2012004265C2777763344 @default.
• W2012004265 hasConceptScore W2012004265C2778635478 @default.
• W2012004265 hasConceptScore W2012004265C2779117757 @default.
• W2012004265 hasConceptScore W2012004265C2779920670 @default.
• W2012004265 hasConceptScore W2012004265C2780786045 @default.

• next