FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012005013> ?p ?o ?g. }

• W2012005013 endingPage "4138" @default.
• W2012005013 startingPage "4134" @default.
• W2012005013 abstract "Class II molecules of the major histocompatibility complex present antigenic peptides to helper T cells. These are heterodimeric glycoproteins consisting of one alpha and one beta chain. Two different alpha/beta heterodimeric conformations as well as the separate alpha and beta chains bind specific peptides. The alpha chain is thought to have one and the beta chain two intramolecular disulfide bonds. In the present study we have reduced these disulfide bonds in the murine major histocompatibility complex molecule I-Ad, which led to the release of bound peptides from all conformations and to unfolding of the separate chains. The separate alpha and beta chains could be refolded to their native structure by reoxidation of the cysteines. Refolding was accompanied by reassembly of the separated chains to the alpha/beta heterodimer. Both the separated alpha and beta chains and the alpha/beta heterodimer bound significantly higher amounts of antigenic peptide after reduction and reoxidation, as compared to the untreated protein." @default.
• W2012005013 created "2016-06-24" @default.
• W2012005013 creator A5041639297 @default.
• W2012005013 creator A5045601856 @default.
• W2012005013 date "1990-06-01" @default.
• W2012005013 modified "2023-09-26" @default.
• W2012005013 title "Refolding and reassembly of separate alpha and beta chains of class II molecules of the major histocompatibility complex leads to increased peptide-binding capacity." @default.
• W2012005013 cites W1481757365 @default.
• W2012005013 cites W1544393375 @default.
• W2012005013 cites W1547913407 @default.
• W2012005013 cites W1963655619 @default.
• W2012005013 cites W1970930845 @default.
• W2012005013 cites W1982034991 @default.
• W2012005013 cites W1990319518 @default.
• W2012005013 cites W1990581038 @default.
• W2012005013 cites W2010336377 @default.
• W2012005013 cites W2022861083 @default.
• W2012005013 cites W2029871341 @default.
• W2012005013 cites W2037729661 @default.
• W2012005013 cites W2044063726 @default.
• W2012005013 cites W2051643639 @default.
• W2012005013 cites W2056927502 @default.
• W2012005013 cites W2058708926 @default.
• W2012005013 cites W2064685114 @default.
• W2012005013 cites W2068707019 @default.
• W2012005013 cites W2068792475 @default.
• W2012005013 cites W2076949662 @default.
• W2012005013 cites W2079606633 @default.
• W2012005013 cites W2085365875 @default.
• W2012005013 cites W2089682997 @default.
• W2012005013 cites W2093617876 @default.
• W2012005013 cites W2220912830 @default.
• W2012005013 doi "https://doi.org/10.1073/pnas.87.11.4134" @default.
• W2012005013 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/54062" @default.
• W2012005013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2349223" @default.
• W2012005013 hasPublicationYear "1990" @default.
• W2012005013 type Work @default.
• W2012005013 sameAs 2012005013 @default.
• W2012005013 citedByCount "29" @default.
• W2012005013 countsByYear W20120050132012 @default.
• W2012005013 countsByYear W20120050132016 @default.
• W2012005013 countsByYear W20120050132020 @default.
• W2012005013 countsByYear W20120050132021 @default.
• W2012005013 crossrefType "journal-article" @default.
• W2012005013 hasAuthorship W2012005013A5041639297 @default.
• W2012005013 hasAuthorship W2012005013A5045601856 @default.
• W2012005013 hasBestOaLocation W20120050132 @default.
• W2012005013 hasConcept C104317684 @default.
• W2012005013 hasConcept C108625454 @default.
• W2012005013 hasConcept C152204938 @default.
• W2012005013 hasConcept C159110408 @default.
• W2012005013 hasConcept C170493617 @default.
• W2012005013 hasConcept C185592680 @default.
• W2012005013 hasConcept C199360897 @default.
• W2012005013 hasConcept C207936829 @default.
• W2012005013 hasConcept C2775944032 @default.
• W2012005013 hasConcept C2776174256 @default.
• W2012005013 hasConcept C2779281246 @default.
• W2012005013 hasConcept C41008148 @default.
• W2012005013 hasConcept C49453240 @default.
• W2012005013 hasConcept C55493867 @default.
• W2012005013 hasConcept C64943373 @default.
• W2012005013 hasConcept C71240020 @default.
• W2012005013 hasConcept C71924100 @default.
• W2012005013 hasConcept C75079739 @default.
• W2012005013 hasConceptScore W2012005013C104317684 @default.
• W2012005013 hasConceptScore W2012005013C108625454 @default.
• W2012005013 hasConceptScore W2012005013C152204938 @default.
• W2012005013 hasConceptScore W2012005013C159110408 @default.
• W2012005013 hasConceptScore W2012005013C170493617 @default.
• W2012005013 hasConceptScore W2012005013C185592680 @default.
• W2012005013 hasConceptScore W2012005013C199360897 @default.
• W2012005013 hasConceptScore W2012005013C207936829 @default.
• W2012005013 hasConceptScore W2012005013C2775944032 @default.
• W2012005013 hasConceptScore W2012005013C2776174256 @default.
• W2012005013 hasConceptScore W2012005013C2779281246 @default.
• W2012005013 hasConceptScore W2012005013C41008148 @default.
• W2012005013 hasConceptScore W2012005013C49453240 @default.
• W2012005013 hasConceptScore W2012005013C55493867 @default.
• W2012005013 hasConceptScore W2012005013C64943373 @default.
• W2012005013 hasConceptScore W2012005013C71240020 @default.
• W2012005013 hasConceptScore W2012005013C71924100 @default.
• W2012005013 hasConceptScore W2012005013C75079739 @default.
• W2012005013 hasIssue "11" @default.
• W2012005013 hasLocation W20120050131 @default.
• W2012005013 hasLocation W20120050132 @default.
• W2012005013 hasLocation W20120050133 @default.
• W2012005013 hasLocation W20120050134 @default.
• W2012005013 hasOpenAccess W2012005013 @default.
• W2012005013 hasPrimaryLocation W20120050131 @default.
• W2012005013 hasRelatedWork W1494192994 @default.
• W2012005013 hasRelatedWork W1513220709 @default.
• W2012005013 hasRelatedWork W1529389226 @default.
• W2012005013 hasRelatedWork W1590886768 @default.
• W2012005013 hasRelatedWork W2071960967 @default.
• W2012005013 hasRelatedWork W2086191285 @default.
• W2012005013 hasRelatedWork W2430384183 @default.
• W2012005013 hasRelatedWork W2889199308 @default.

• next