FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012005719> ?p ?o ?g. }

• W2012005719 endingPage "50" @default.
• W2012005719 startingPage "29" @default.
• W2012005719 abstract "Electrical impedance of cerebral cortex was measured at 1.0 kHz with low current levels (10−13 A per square micron of electrode surface). Changes in impedance were observed after topical application of calcium and magnesium solutions. These modifications were further evaluated by asphyxiation, and by dehydration with intravenous urea. Asphyxiation of untreated cortex caused an initial fall in resistance and raised capacitance rapidly followed by raised resistance and reduced capacitance. Repeated topical application of small amounts of calcium solutions induced a progressive rise in resistance, typically between 20 and 30% of baseline values 10–20 KΩ. This increased impedance reached a plateau after 30–50 min, and further application of calcium was without effect. By contrast with untreated cortex, asphyxiation was followed by a rapid fall in resistance to values around baseline levels. This impedance curve was thus biphasic, with an inverse relationship between the size of the calcium-induced rise and the ensuing fall during asphyxiation. On the other hand, magnesium ions in equivalent amounts exerted only minor effects on cortical impedance, and subsequent asphyxiation produced a large impedance increase, as in untreated cortex. However, magnesium ions produced effects similar to calcium in normal and asphyxiated cortex, if the cortex was first dehydrated with intravenous urea, and even though urea alone was without major effects on impedance. Prior dehydration with urea had no effect on the course of impedance changes produced by calcium. These findings are interpreted in terms of conductance of impedance measuring currents mainly through an extracellular space containing a hydrated network of macromolecules that blend with similar external coats on cell membrane, and which bear numerous cationic binding sites. Evidence is presented in electron micrographs prepared with aldehyde fixation that excess calcium ions narrow intercellular spaces and that these changes reverse with asphyxiation. No such narrowing was induced by urea. On the other hand, magnesium ions were associated with much augmented intercellular spaces. It is proposed that conductance in the extracellular space is determined by the state of its structural elements, including interdependent factors such as hydration and divalent cation binding, as well as by changes in its cross-sectional area. The preeminent role of calcium ions in altering tissue impedance is discussed in relation to membrane excitation, with competitive binding of calcium and hydrogen ions to anionic macromolecular sites. Evidence relating these results to information storage at the neuronal surface is discussed." @default.
• W2012005719 created "2016-06-24" @default.
• W2012005719 creator A5016147502 @default.
• W2012005719 creator A5042501959 @default.
• W2012005719 creator A5053631943 @default.
• W2012005719 creator A5075573915 @default.
• W2012005719 creator A5086054907 @default.
• W2012005719 date "1969-01-01" @default.
• W2012005719 modified "2023-09-26" @default.
• W2012005719 title "Divalent cations in cerebral impedance and cell membrane morphology" @default.
• W2012005719 cites W1971488196 @default.
• W2012005719 cites W2002057610 @default.
• W2012005719 cites W2003834031 @default.
• W2012005719 cites W2005116984 @default.
• W2012005719 cites W2008047399 @default.
• W2012005719 cites W2009222437 @default.
• W2012005719 cites W2016085917 @default.
• W2012005719 cites W2019126938 @default.
• W2012005719 cites W2021504748 @default.
• W2012005719 cites W2022433060 @default.
• W2012005719 cites W2023753204 @default.
• W2012005719 cites W2024859042 @default.
• W2012005719 cites W2026193511 @default.
• W2012005719 cites W2028459092 @default.
• W2012005719 cites W2033648345 @default.
• W2012005719 cites W2036340219 @default.
• W2012005719 cites W2047487048 @default.
• W2012005719 cites W2048928740 @default.
• W2012005719 cites W2057133504 @default.
• W2012005719 cites W2059368688 @default.
• W2012005719 cites W2060797318 @default.
• W2012005719 cites W2061063315 @default.
• W2012005719 cites W2063623344 @default.
• W2012005719 cites W2073951267 @default.
• W2012005719 cites W2105815571 @default.
• W2012005719 cites W2161898659 @default.
• W2012005719 cites W2164976975 @default.
• W2012005719 cites W2206678636 @default.
• W2012005719 cites W2321797656 @default.
• W2012005719 cites W2341541642 @default.
• W2012005719 cites W2342114363 @default.
• W2012005719 cites W2405250637 @default.
• W2012005719 cites W2410796612 @default.
• W2012005719 cites W2421280303 @default.
• W2012005719 cites W2429443139 @default.
• W2012005719 cites W2441506123 @default.
• W2012005719 cites W2486372011 @default.
• W2012005719 cites W4298379992 @default.
• W2012005719 cites W2138160097 @default.
• W2012005719 doi "https://doi.org/10.1016/0014-4886(69)90031-4" @default.
• W2012005719 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/5765005" @default.
• W2012005719 hasPublicationYear "1969" @default.
• W2012005719 type Work @default.
• W2012005719 sameAs 2012005719 @default.
• W2012005719 citedByCount "31" @default.
• W2012005719 crossrefType "journal-article" @default.
• W2012005719 hasAuthorship W2012005719A5016147502 @default.
• W2012005719 hasAuthorship W2012005719A5042501959 @default.
• W2012005719 hasAuthorship W2012005719A5053631943 @default.
• W2012005719 hasAuthorship W2012005719A5075573915 @default.
• W2012005719 hasAuthorship W2012005719A5086054907 @default.
• W2012005719 hasConcept C114614502 @default.
• W2012005719 hasConcept C119599485 @default.
• W2012005719 hasConcept C121932024 @default.
• W2012005719 hasConcept C12554922 @default.
• W2012005719 hasConcept C127413603 @default.
• W2012005719 hasConcept C169760540 @default.
• W2012005719 hasConcept C17829176 @default.
• W2012005719 hasConcept C178790620 @default.
• W2012005719 hasConcept C185592680 @default.
• W2012005719 hasConcept C2777348757 @default.
• W2012005719 hasConcept C2780365088 @default.
• W2012005719 hasConcept C28406088 @default.
• W2012005719 hasConcept C33923547 @default.
• W2012005719 hasConcept C519063684 @default.
• W2012005719 hasConcept C543218039 @default.
• W2012005719 hasConcept C55493867 @default.
• W2012005719 hasConcept C86803240 @default.
• W2012005719 hasConceptScore W2012005719C114614502 @default.
• W2012005719 hasConceptScore W2012005719C119599485 @default.
• W2012005719 hasConceptScore W2012005719C121932024 @default.
• W2012005719 hasConceptScore W2012005719C12554922 @default.
• W2012005719 hasConceptScore W2012005719C127413603 @default.
• W2012005719 hasConceptScore W2012005719C169760540 @default.
• W2012005719 hasConceptScore W2012005719C17829176 @default.
• W2012005719 hasConceptScore W2012005719C178790620 @default.
• W2012005719 hasConceptScore W2012005719C185592680 @default.
• W2012005719 hasConceptScore W2012005719C2777348757 @default.
• W2012005719 hasConceptScore W2012005719C2780365088 @default.
• W2012005719 hasConceptScore W2012005719C28406088 @default.
• W2012005719 hasConceptScore W2012005719C33923547 @default.
• W2012005719 hasConceptScore W2012005719C519063684 @default.
• W2012005719 hasConceptScore W2012005719C543218039 @default.
• W2012005719 hasConceptScore W2012005719C55493867 @default.
• W2012005719 hasConceptScore W2012005719C86803240 @default.
• W2012005719 hasIssue "1" @default.
• W2012005719 hasLocation W20120057191 @default.
• W2012005719 hasLocation W20120057192 @default.

• next