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• W2012007471 abstract "Loss of periodontal support and eventually tooth loss is a common finding among acquired immunodeficiency syndrome (AIDS) patients. The cause of this destruction may be an increase in periodontal disease activity at sites within the same individual and also may be related to an increase in the pro-inflammatory cytokines, diffused through the gingival crevicular sulcus in AIDS patients. A study was undertaken to determine the relative levels of the pro-inflammatory cytokines, interleukin 1 beta (IL-1 beta), IL-6, and tumor necrosis factor alpha (TNF-alpha), in gingival crevicular fluid collected from the deep (> 5 mm periodontal pocket depth) and shallow (< or = 3 mm periodontal pocket depth) periodontal pockets of 39 HIV-1-infected patients and 20 age-, race- and sex-matched uninfected controls. Complete medical history including risk factors such as intravenous drug abuse was taken. Gingival crevicular fluid samples were collected on periopaper strips. Cytokines were estimated by solid-phase enzyme-linked immunosorbent assay. To assess the degree of HIV activity, the viral load of these patients was determined by an Amplicor HIV-1 monitor kit using reverse transcriptase polymerase chain reaction. Gingival crevicular fluid from HIV-1-infected patients showed a two-fold increase in both IL-1 beta and TNF-alpha in deep periodontal pockets in comparison to shallow pockets, whereas IL-6 increased 1.8-fold. There was a significant (P < 0.05) increase in IL-1 beta, IL-6 and TNF-alpha in gingival crevicular fluid (both shallow and deep pockets) from HIV-1-infected patients in comparison to uninfected controls and also significantly elevated in deep versus shallow pockets in these patients. Although IL-1 beta, L-6 and TNF-alpha levels among HIV-1-infected patients with a high viral load (> 10,000 copies/ml) were higher than those from patients with a low viral load (< 400 copies/ml), only the increase in IL-1 beta level associated with deep pockets was significant (P < 0.05). There was also a trend of an increase in all the three cytokines among intravenous drug-abusing HIV-1-infected patients in comparison to non-intravenous drug abusers, but only the difference in IL-1 beta levels from deep pockets reached significance (P < 0.05). These enhanced pro-inflammatory cytokine levels in the gingival crevicular fluid of HIV-positive patients may be an important factor in causing the advanced periodontal lesions sometimes observed in HIV-positive patients." @default.
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• W2012007471 date "2000-04-01" @default.
• W2012007471 modified "2023-09-27" @default.
• W2012007471 title "Enhanced interleukin 1β, interleukin 6 and tumor necrosis factor α in gingival crevicular fluid from periodontal pockets of patients infected with human immunodeficiency virus 1" @default.
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• W2012007471 doi "https://doi.org/10.1034/j.1399-302x.2000.150201.x" @default.
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