FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012010386> ?p ?o ?g. }

• W2012010386 endingPage "66" @default.
• W2012010386 startingPage "59" @default.
• W2012010386 abstract "The renin-angiotensin system (RAS) plays a central role in the pathogenesis of hypertension. Recently, we discovered that 1α,25-dihydroxyvitamin D3 [1,25(OH)2D3] functions as a negative endocrine regulator of renin biosynthesis, which provides a molecular basis to explore the potential of Vitamin D analogs as renin inhibitors to control the RAS. To search for renin-inhibiting Vitamin D analogs, we screened 20 Vitamin D analog compounds using As4.1-hVDR cell (a juxtaglomerular cell line) culture by Northern blot and luciferase reporter assays. We found that the Gemini compounds, which have two side-chains at carbon-20 position, were particularly active in suppressing renin expression. Eight Gemini compounds were identified that were equally or 10- to 100-times more potent than 1,25(OH)2D3 in renin inhibition. These Gemini compounds also potently stimulate 25-hydroxyvitamin D 24-hydroxylase expression in As4.1-hVDR cells. Administration of compound RO-27-5646 [1,25-dihydroxy-21-(3-methyl-3-hydroxy-butyl)-19-nor-cholecalciferol] in mice caused a marked reduction in renal renin mRNA expression without invoking severe hypercalcemia as seen in 1,25(OH)2D3 treatment. These data establish in principle that Vitamin D analogs can indeed inhibit renin expression in vitro and in vivo, and support the notion that low calcemic Vitamin D analogs can potentially be used as therapeutic agents to control the RAS." @default.
• W2012010386 created "2016-06-24" @default.
• W2012010386 creator A5034479183 @default.
• W2012010386 creator A5044144261 @default.
• W2012010386 creator A5055088908 @default.
• W2012010386 creator A5089137150 @default.
• W2012010386 date "2005-06-01" @default.
• W2012010386 modified "2023-10-03" @default.
• W2012010386 title "Analogs of 1α,25-dihydroxyvitamin D3 as novel inhibitors of renin biosynthesis" @default.
• W2012010386 cites W1512662047 @default.
• W2012010386 cites W1828239849 @default.
• W2012010386 cites W1863226311 @default.
• W2012010386 cites W1879176953 @default.
• W2012010386 cites W1964616785 @default.
• W2012010386 cites W1969282066 @default.
• W2012010386 cites W1984135090 @default.
• W2012010386 cites W1990286587 @default.
• W2012010386 cites W2003350706 @default.
• W2012010386 cites W2005772252 @default.
• W2012010386 cites W2007908315 @default.
• W2012010386 cites W2015756205 @default.
• W2012010386 cites W2018477486 @default.
• W2012010386 cites W2025589168 @default.
• W2012010386 cites W2040803575 @default.
• W2012010386 cites W2050684606 @default.
• W2012010386 cites W2072811093 @default.
• W2012010386 cites W2079327982 @default.
• W2012010386 cites W2084654608 @default.
• W2012010386 cites W2086730539 @default.
• W2012010386 cites W2102185935 @default.
• W2012010386 cites W2105417592 @default.
• W2012010386 cites W2107865114 @default.
• W2012010386 cites W2141655045 @default.
• W2012010386 cites W2146227799 @default.
• W2012010386 cites W2156887647 @default.
• W2012010386 cites W2162830049 @default.
• W2012010386 cites W2163957982 @default.
• W2012010386 cites W2325791828 @default.
• W2012010386 cites W2342067247 @default.
• W2012010386 cites W4233469193 @default.
• W2012010386 cites W4247939814 @default.
• W2012010386 doi "https://doi.org/10.1016/j.jsbmb.2005.02.008" @default.
• W2012010386 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15878826" @default.
• W2012010386 hasPublicationYear "2005" @default.
• W2012010386 type Work @default.
• W2012010386 sameAs 2012010386 @default.
• W2012010386 citedByCount "76" @default.
• W2012010386 countsByYear W20120103862012 @default.
• W2012010386 countsByYear W20120103862013 @default.
• W2012010386 countsByYear W20120103862014 @default.
• W2012010386 countsByYear W20120103862015 @default.
• W2012010386 countsByYear W20120103862016 @default.
• W2012010386 countsByYear W20120103862017 @default.
• W2012010386 countsByYear W20120103862018 @default.
• W2012010386 countsByYear W20120103862019 @default.
• W2012010386 countsByYear W20120103862020 @default.
• W2012010386 countsByYear W20120103862021 @default.
• W2012010386 countsByYear W20120103862022 @default.
• W2012010386 crossrefType "journal-article" @default.
• W2012010386 hasAuthorship W2012010386A5034479183 @default.
• W2012010386 hasAuthorship W2012010386A5044144261 @default.
• W2012010386 hasAuthorship W2012010386A5055088908 @default.
• W2012010386 hasAuthorship W2012010386A5089137150 @default.
• W2012010386 hasConcept C124490489 @default.
• W2012010386 hasConcept C126322002 @default.
• W2012010386 hasConcept C134018914 @default.
• W2012010386 hasConcept C150903083 @default.
• W2012010386 hasConcept C181199279 @default.
• W2012010386 hasConcept C185592680 @default.
• W2012010386 hasConcept C198710026 @default.
• W2012010386 hasConcept C202751555 @default.
• W2012010386 hasConcept C207001950 @default.
• W2012010386 hasConcept C2776940978 @default.
• W2012010386 hasConcept C2780106736 @default.
• W2012010386 hasConcept C54355233 @default.
• W2012010386 hasConcept C553450214 @default.
• W2012010386 hasConcept C55493867 @default.
• W2012010386 hasConcept C71924100 @default.
• W2012010386 hasConcept C81885089 @default.
• W2012010386 hasConcept C84393581 @default.
• W2012010386 hasConcept C86803240 @default.
• W2012010386 hasConcept C98274493 @default.
• W2012010386 hasConceptScore W2012010386C124490489 @default.
• W2012010386 hasConceptScore W2012010386C126322002 @default.
• W2012010386 hasConceptScore W2012010386C134018914 @default.
• W2012010386 hasConceptScore W2012010386C150903083 @default.
• W2012010386 hasConceptScore W2012010386C181199279 @default.
• W2012010386 hasConceptScore W2012010386C185592680 @default.
• W2012010386 hasConceptScore W2012010386C198710026 @default.
• W2012010386 hasConceptScore W2012010386C202751555 @default.
• W2012010386 hasConceptScore W2012010386C207001950 @default.
• W2012010386 hasConceptScore W2012010386C2776940978 @default.
• W2012010386 hasConceptScore W2012010386C2780106736 @default.
• W2012010386 hasConceptScore W2012010386C54355233 @default.
• W2012010386 hasConceptScore W2012010386C553450214 @default.
• W2012010386 hasConceptScore W2012010386C55493867 @default.
• W2012010386 hasConceptScore W2012010386C71924100 @default.
• W2012010386 hasConceptScore W2012010386C81885089 @default.

• next