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- W2012012167 abstract "The pathogenesis of various inflammatory cutaneous diseases such as psoriasis, atopic dermatitis and mycosis fungoides relies greatly on the abnormal function of T cells. Fundamental knowledge of the role of T cells in the cutaneous immune response has led to the development and production of biologic molecules designed to block T cell function at various steps, specifically activation (i.e. alefacept, efalizumab), trafficking into inflamed skin (i.e. efalizumab) and effector function under cytokine control (i.e. etanercept, infliximab, adalimumab, and anti-IL-12 antibody). We review the immune abnormalities and the role of T cells in psoriasis, and the recent biologic therapies, which share the common mission to hinder T cell activity in inflammatory diseases. An advantage from the preciseness of these biologic therapies is the potential limit of non-specific and potentially devastating organ toxicity, which commonly plagues other systemic therapies." @default.
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- W2012012167 date "2007-01-01" @default.
- W2012012167 modified "2023-09-25" @default.
- W2012012167 title "Anti-Inflammatory Activities of Stilbene Analogs for Targeting Autoimmune Diseases" @default.
- W2012012167 doi "https://doi.org/10.1016/j.clim.2007.03.551" @default.
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