Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012014057> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2012014057 endingPage "207" @default.
- W2012014057 startingPage "203" @default.
- W2012014057 abstract "Diseases which affect mucosal surfaces cause considerable mortality and morbidity. New vaccine technologies are now available which justify a reappraisal of oral delivery not only for infectious disease control but also to control mucosal physiological processes such as fertility. Biodegradable microspheres have been investigated for their use as an oral delivery vehicle in rats using a recombinant antigen derived from fox sperm. Unencapsulated antigen administered in saline by the oral route produced a negligible response although an improved response was obtained if administered directly into the duodenum. This response was considerably enhanced if Peyer's patch (PP) priming was performed by direct injection of antigen in Freund's complete adjuvant (FCA) prior to intraduodenal (ID) delivery. In contrast, microencapsulated antigen given orally produced a substantial response, which was predominantly IgA specific, and almost equal in magnitude to that obtained by PP priming and ID boosting with native antigen. Direct ID delivery produced a similar response but when PP were primed with microencapsulated antigen in FCA the response to ID boosting was greater than with any of the other protocols investigated. These data demonstrate the efficacy of biodegradable microspheres in producing an IgA antibody response following oral vaccination." @default.
- W2012014057 created "2016-06-24" @default.
- W2012014057 creator A5030747893 @default.
- W2012014057 creator A5037147711 @default.
- W2012014057 creator A5052314516 @default.
- W2012014057 creator A5062246892 @default.
- W2012014057 date "1994-10-01" @default.
- W2012014057 modified "2023-10-10" @default.
- W2012014057 title "Induction of specific IgA responses in rats after oral vaccination with biodegradable microspheres containing a recombinant protein" @default.
- W2012014057 cites W1975133899 @default.
- W2012014057 cites W1992497253 @default.
- W2012014057 cites W2000064765 @default.
- W2012014057 cites W2015376750 @default.
- W2012014057 cites W2043795458 @default.
- W2012014057 cites W2049502469 @default.
- W2012014057 cites W2061288775 @default.
- W2012014057 cites W2063196721 @default.
- W2012014057 doi "https://doi.org/10.1016/0165-2478(94)90087-6" @default.
- W2012014057 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7890321" @default.
- W2012014057 hasPublicationYear "1994" @default.
- W2012014057 type Work @default.
- W2012014057 sameAs 2012014057 @default.
- W2012014057 citedByCount "23" @default.
- W2012014057 countsByYear W20120140572015 @default.
- W2012014057 countsByYear W20120140572022 @default.
- W2012014057 crossrefType "journal-article" @default.
- W2012014057 hasAuthorship W2012014057A5030747893 @default.
- W2012014057 hasAuthorship W2012014057A5037147711 @default.
- W2012014057 hasAuthorship W2012014057A5052314516 @default.
- W2012014057 hasAuthorship W2012014057A5062246892 @default.
- W2012014057 hasConcept C100701293 @default.
- W2012014057 hasConcept C126322002 @default.
- W2012014057 hasConcept C147483822 @default.
- W2012014057 hasConcept C203014093 @default.
- W2012014057 hasConcept C22070199 @default.
- W2012014057 hasConcept C2776809568 @default.
- W2012014057 hasConcept C2776946954 @default.
- W2012014057 hasConcept C2777863537 @default.
- W2012014057 hasConcept C2780868878 @default.
- W2012014057 hasConcept C2910153128 @default.
- W2012014057 hasConcept C59822182 @default.
- W2012014057 hasConcept C71924100 @default.
- W2012014057 hasConcept C81444415 @default.
- W2012014057 hasConcept C86803240 @default.
- W2012014057 hasConcept C8891405 @default.
- W2012014057 hasConceptScore W2012014057C100701293 @default.
- W2012014057 hasConceptScore W2012014057C126322002 @default.
- W2012014057 hasConceptScore W2012014057C147483822 @default.
- W2012014057 hasConceptScore W2012014057C203014093 @default.
- W2012014057 hasConceptScore W2012014057C22070199 @default.
- W2012014057 hasConceptScore W2012014057C2776809568 @default.
- W2012014057 hasConceptScore W2012014057C2776946954 @default.
- W2012014057 hasConceptScore W2012014057C2777863537 @default.
- W2012014057 hasConceptScore W2012014057C2780868878 @default.
- W2012014057 hasConceptScore W2012014057C2910153128 @default.
- W2012014057 hasConceptScore W2012014057C59822182 @default.
- W2012014057 hasConceptScore W2012014057C71924100 @default.
- W2012014057 hasConceptScore W2012014057C81444415 @default.
- W2012014057 hasConceptScore W2012014057C86803240 @default.
- W2012014057 hasConceptScore W2012014057C8891405 @default.
- W2012014057 hasIssue "3" @default.
- W2012014057 hasLocation W20120140571 @default.
- W2012014057 hasLocation W20120140572 @default.
- W2012014057 hasOpenAccess W2012014057 @default.
- W2012014057 hasPrimaryLocation W20120140571 @default.
- W2012014057 hasRelatedWork W14192019 @default.
- W2012014057 hasRelatedWork W173086023 @default.
- W2012014057 hasRelatedWork W1933752105 @default.
- W2012014057 hasRelatedWork W1964806032 @default.
- W2012014057 hasRelatedWork W2007435219 @default.
- W2012014057 hasRelatedWork W2079447530 @default.
- W2012014057 hasRelatedWork W2102668441 @default.
- W2012014057 hasRelatedWork W2120143170 @default.
- W2012014057 hasRelatedWork W2318735859 @default.
- W2012014057 hasRelatedWork W247969383 @default.
- W2012014057 hasVolume "42" @default.
- W2012014057 isParatext "false" @default.
- W2012014057 isRetracted "false" @default.
- W2012014057 magId "2012014057" @default.
- W2012014057 workType "article" @default.