FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012014345> ?p ?o ?g. }

• W2012014345 endingPage "1795" @default.
• W2012014345 startingPage "1787" @default.
• W2012014345 abstract "Intact lymphocytes from patients with cystic fibrosis (CF) produce significantly (P less than 0.001) less adenosine 3':5' cyclic monophosphate (cAMP) than normal lymphocytes in response to isoproterenol (10(-8)-10(-4) M), although the basal cAMP content and the response to prostaglandin E1 are normal. Obligate heterozygotes for CF have significantly (P less than 0.005) reduced cAMP response to isoproterenol as well, suggesting a genetic component in the beta adrenergic deficiency in CF. The number of beta adrenergic receptors, as determined by equilibrium binding of [3H]dihydroalprenolol to lymphocyte particulates, is the same in normal lymphocytes (969 +/- 165 receptors/cell) and lymphocytes from patients with CF (1,333 +/- 263 receptors/cell). Binding properties of the receptor for both antagonist and agonist, as assessed by KD for dihydroalprenolol and Ki for (-)-isoproterenol, are also normal in the CF lymphocytes. Similarly, in granulocytes from patients with CF, the cAMP response to isoproterenol (10(-8)-10(-4) M) is significantly reduced compared with healthy controls (P less than 0.03), as is the response of granulocytes from obligate heterozygotes (P less than 0.05). Again, the basal cAMP levels and the response to prostaglandin E1 are normal. The number of beta adrenergic receptors, as determined by equilibrium binding of [3H]dihydroalprenolol to granulocyte particulates, was the same in normal (1,462 +/- 249 receptors/cell) and CF (1,621 +/- 221 receptors/cell) preparations. Binding properties of the receptor for both agonist and antagonist, as assessed by KD for dihydroalprenolol and Ki for isoproterenol, are normal in CF granulocyte particulates. The lymphocyte and granulocyte beta adrenergic defect in CF cannot be explained by abnormalities of the beta adrenergic receptor or of adenylate cyclase itself. Receptor-cyclase coupling is the most likely site of the heritable beta adrenergic defect in CF." @default.
• W2012014345 created "2016-06-24" @default.
• W2012014345 creator A5011241944 @default.
• W2012014345 creator A5021719854 @default.
• W2012014345 creator A5044301459 @default.
• W2012014345 creator A5069291485 @default.
• W2012014345 creator A5087441712 @default.
• W2012014345 date "1983-06-01" @default.
• W2012014345 modified "2023-09-28" @default.
• W2012014345 title "Beta adrenergic receptors in lymphocytes and granulocytes from patients with cystic fibrosis." @default.
• W2012014345 cites W112895539 @default.
• W2012014345 cites W1890989648 @default.
• W2012014345 cites W1971964485 @default.
• W2012014345 cites W1993033457 @default.
• W2012014345 cites W1995135022 @default.
• W2012014345 cites W1996865058 @default.
• W2012014345 cites W2025137533 @default.
• W2012014345 cites W2056528694 @default.
• W2012014345 cites W2069215040 @default.
• W2012014345 cites W2074631079 @default.
• W2012014345 cites W2075676530 @default.
• W2012014345 cites W2087243566 @default.
• W2012014345 cites W2128635872 @default.
• W2012014345 cites W2134225040 @default.
• W2012014345 cites W2155502587 @default.
• W2012014345 cites W2341814959 @default.
• W2012014345 cites W2415713933 @default.
• W2012014345 cites W2462297192 @default.
• W2012014345 cites W2466219086 @default.
• W2012014345 cites W45574617 @default.
• W2012014345 cites W87082738 @default.
• W2012014345 doi "https://doi.org/10.1172/jci110934" @default.
• W2012014345 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/370384" @default.
• W2012014345 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6306054" @default.
• W2012014345 hasPublicationYear "1983" @default.
• W2012014345 type Work @default.
• W2012014345 sameAs 2012014345 @default.
• W2012014345 citedByCount "38" @default.
• W2012014345 countsByYear W20120143452018 @default.
• W2012014345 crossrefType "journal-article" @default.
• W2012014345 hasAuthorship W2012014345A5011241944 @default.
• W2012014345 hasAuthorship W2012014345A5021719854 @default.
• W2012014345 hasAuthorship W2012014345A5044301459 @default.
• W2012014345 hasAuthorship W2012014345A5069291485 @default.
• W2012014345 hasAuthorship W2012014345A5087441712 @default.
• W2012014345 hasBestOaLocation W20120143451 @default.
• W2012014345 hasConcept C126322002 @default.
• W2012014345 hasConcept C134018914 @default.
• W2012014345 hasConcept C170493617 @default.
• W2012014345 hasConcept C185592680 @default.
• W2012014345 hasConcept C2777761686 @default.
• W2012014345 hasConcept C2778438532 @default.
• W2012014345 hasConcept C2778938600 @default.
• W2012014345 hasConcept C2780275434 @default.
• W2012014345 hasConcept C40465926 @default.
• W2012014345 hasConcept C58732023 @default.
• W2012014345 hasConcept C71924100 @default.
• W2012014345 hasConcept C86803240 @default.
• W2012014345 hasConceptScore W2012014345C126322002 @default.
• W2012014345 hasConceptScore W2012014345C134018914 @default.
• W2012014345 hasConceptScore W2012014345C170493617 @default.
• W2012014345 hasConceptScore W2012014345C185592680 @default.
• W2012014345 hasConceptScore W2012014345C2777761686 @default.
• W2012014345 hasConceptScore W2012014345C2778438532 @default.
• W2012014345 hasConceptScore W2012014345C2778938600 @default.
• W2012014345 hasConceptScore W2012014345C2780275434 @default.
• W2012014345 hasConceptScore W2012014345C40465926 @default.
• W2012014345 hasConceptScore W2012014345C58732023 @default.
• W2012014345 hasConceptScore W2012014345C71924100 @default.
• W2012014345 hasConceptScore W2012014345C86803240 @default.
• W2012014345 hasIssue "6" @default.
• W2012014345 hasLocation W20120143451 @default.
• W2012014345 hasLocation W20120143452 @default.
• W2012014345 hasLocation W20120143453 @default.
• W2012014345 hasLocation W20120143454 @default.
• W2012014345 hasLocation W20120143455 @default.
• W2012014345 hasOpenAccess W2012014345 @default.
• W2012014345 hasPrimaryLocation W20120143451 @default.
• W2012014345 hasRelatedWork W1966839547 @default.
• W2012014345 hasRelatedWork W1997342359 @default.
• W2012014345 hasRelatedWork W2009443436 @default.
• W2012014345 hasRelatedWork W2029150774 @default.
• W2012014345 hasRelatedWork W2030500866 @default.
• W2012014345 hasRelatedWork W2032657822 @default.
• W2012014345 hasRelatedWork W2052453588 @default.
• W2012014345 hasRelatedWork W2060226832 @default.
• W2012014345 hasRelatedWork W2156567718 @default.
• W2012014345 hasRelatedWork W474420078 @default.
• W2012014345 hasVolume "71" @default.
• W2012014345 isParatext "false" @default.
• W2012014345 isRetracted "false" @default.
• W2012014345 magId "2012014345" @default.
• W2012014345 workType "article" @default.