Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012016405> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W2012016405 endingPage "139" @default.
- W2012016405 startingPage "139" @default.
- W2012016405 abstract "The catabolism of phosphatidylcholine (PtdCho) has been studied in cultured murine neuroblastoma (N1E-115), C6 glioma, rat brain primary glia, and human fibroblast cells. Cells were pulse labelled for 96 h with [methyl-3H]choline followed by a chase for up to 24 h in medium containing 4 mM choline. Measurement of the radioactivity and mass of choline-containing compounds in these cells indicated that the major degradative pathway is PtdCho → lysophosphatidylcholine (lysoPtdCho) → glycerophosphocholine (GroPCho) → choline. At all times during the chase, PtdCho, sphingomyelin and lysoPtdCho comprised 72–92% of the cell-associated radioactivity; the remaining 10–30% was water-soluble and was chiefly GroPCho (30–80%) in all cell lines. In fibroblasts, however, phosphocholine (PCho) was also a major labelled water-soluble component (33–54%). The specific activity of GroPCho closely parallelled that of PtdCho in fibroblasts, but decreased faster than PtdCho in C6 and N1E-115 cells. We postulate that this may be due to distinct pools of PtdCho in the cell with differing rates of turnover. The changes in specific activity of PCho suggest that the major portion is formed by synthesis rather than as a degradative product. However, the inability to reduce the specific activity of this fraction to that of the intracellular choline suggests that a portion may be derived from either PtdCho or GroPCho." @default.
- W2012016405 created "2016-06-24" @default.
- W2012016405 creator A5050283830 @default.
- W2012016405 creator A5058806166 @default.
- W2012016405 creator A5062820211 @default.
- W2012016405 date "2010-06-01" @default.
- W2012016405 modified "2023-10-18" @default.
- W2012016405 title "545 Antiestrogen 4-OHT activity in lung cancer in vitro" @default.
- W2012016405 doi "https://doi.org/10.1016/s1359-6349(10)71346-x" @default.
- W2012016405 hasPublicationYear "2010" @default.
- W2012016405 type Work @default.
- W2012016405 sameAs 2012016405 @default.
- W2012016405 citedByCount "0" @default.
- W2012016405 crossrefType "journal-article" @default.
- W2012016405 hasAuthorship W2012016405A5050283830 @default.
- W2012016405 hasAuthorship W2012016405A5058806166 @default.
- W2012016405 hasAuthorship W2012016405A5062820211 @default.
- W2012016405 hasConcept C185592680 @default.
- W2012016405 hasConcept C202751555 @default.
- W2012016405 hasConcept C2776330855 @default.
- W2012016405 hasConcept C2776923060 @default.
- W2012016405 hasConcept C2778596009 @default.
- W2012016405 hasConcept C2778918659 @default.
- W2012016405 hasConcept C2780601828 @default.
- W2012016405 hasConcept C2781123555 @default.
- W2012016405 hasConcept C41625074 @default.
- W2012016405 hasConcept C54355233 @default.
- W2012016405 hasConcept C55493867 @default.
- W2012016405 hasConcept C61322309 @default.
- W2012016405 hasConcept C81885089 @default.
- W2012016405 hasConcept C86803240 @default.
- W2012016405 hasConcept C95444343 @default.
- W2012016405 hasConceptScore W2012016405C185592680 @default.
- W2012016405 hasConceptScore W2012016405C202751555 @default.
- W2012016405 hasConceptScore W2012016405C2776330855 @default.
- W2012016405 hasConceptScore W2012016405C2776923060 @default.
- W2012016405 hasConceptScore W2012016405C2778596009 @default.
- W2012016405 hasConceptScore W2012016405C2778918659 @default.
- W2012016405 hasConceptScore W2012016405C2780601828 @default.
- W2012016405 hasConceptScore W2012016405C2781123555 @default.
- W2012016405 hasConceptScore W2012016405C41625074 @default.
- W2012016405 hasConceptScore W2012016405C54355233 @default.
- W2012016405 hasConceptScore W2012016405C55493867 @default.
- W2012016405 hasConceptScore W2012016405C61322309 @default.
- W2012016405 hasConceptScore W2012016405C81885089 @default.
- W2012016405 hasConceptScore W2012016405C86803240 @default.
- W2012016405 hasConceptScore W2012016405C95444343 @default.
- W2012016405 hasIssue "5" @default.
- W2012016405 hasLocation W20120164051 @default.
- W2012016405 hasOpenAccess W2012016405 @default.
- W2012016405 hasPrimaryLocation W20120164051 @default.
- W2012016405 hasRelatedWork W1973037854 @default.
- W2012016405 hasRelatedWork W1978446484 @default.
- W2012016405 hasRelatedWork W1981845884 @default.
- W2012016405 hasRelatedWork W2012016405 @default.
- W2012016405 hasRelatedWork W2078237283 @default.
- W2012016405 hasRelatedWork W2082165507 @default.
- W2012016405 hasRelatedWork W2083303157 @default.
- W2012016405 hasRelatedWork W2092874303 @default.
- W2012016405 hasRelatedWork W2166004088 @default.
- W2012016405 hasRelatedWork W2341578418 @default.
- W2012016405 hasVolume "8" @default.
- W2012016405 isParatext "false" @default.
- W2012016405 isRetracted "false" @default.
- W2012016405 magId "2012016405" @default.
- W2012016405 workType "article" @default.