Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012019322> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2012019322 abstract "The aim of this investigation was to study the effect of temperature on the permeation of imipramine hydrochloride (IMH) across rat skin from two different vehicles. Differential scanning calorimetry (DSC) was used to characterize the phase transitions of rat epidermis and extracted rat SC lipids, and the transition temperatures were correlated with the permeability of IMH at different temperatures. Permeability of IMH from ethanol and propylene glycol (PG) was determined at five different temperatures and observed that a significant increase in IMH permeability occurred 45 degrees C from both the vehicles. Further, high energies of activation for rat skin permeation suggested that IMH diffuses across intercellular lipid matrix and therefore any change in the packing of SC lipids will have an effect on IMH permeation. Three endotherms T(1), T(2) and T(3) of rat epidermis were observed in DSC thermograms at 44, 53 and 64 degrees C and were assigned as transitions corresponding to orthorhombic to hexagonal, hexagonal to more disordered phase and melting of lipids with high cholesterol content, respectively. The high permeability values of IMH above 45 degrees C were therefore reasoned to be because of orthorhombic to hexagonal phase transition in rat skin from close to that temperature." @default.
- W2012019322 created "2016-06-24" @default.
- W2012019322 creator A5068472097 @default.
- W2012019322 creator A5070865626 @default.
- W2012019322 date "2003-01-01" @default.
- W2012019322 modified "2023-09-27" @default.
- W2012019322 title "Effect of temperature on imipramine hydrochloride permeation: role of lipid bilayer arrangement and chemical composition of rat skin" @default.
- W2012019322 cites W1971324979 @default.
- W2012019322 cites W1985688513 @default.
- W2012019322 cites W1995023052 @default.
- W2012019322 cites W1995515519 @default.
- W2012019322 cites W2012773267 @default.
- W2012019322 cites W2022465570 @default.
- W2012019322 cites W2024409040 @default.
- W2012019322 cites W2032066103 @default.
- W2012019322 cites W2034191594 @default.
- W2012019322 cites W2048332046 @default.
- W2012019322 cites W2049982583 @default.
- W2012019322 cites W2069125729 @default.
- W2012019322 cites W2074846432 @default.
- W2012019322 cites W2080938145 @default.
- W2012019322 cites W2082907536 @default.
- W2012019322 cites W2089250271 @default.
- W2012019322 cites W2149300987 @default.
- W2012019322 doi "https://doi.org/10.1016/s0378-5173(02)00550-1" @default.
- W2012019322 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12480294" @default.
- W2012019322 hasPublicationYear "2003" @default.
- W2012019322 type Work @default.
- W2012019322 sameAs 2012019322 @default.
- W2012019322 citedByCount "12" @default.
- W2012019322 crossrefType "journal-article" @default.
- W2012019322 hasAuthorship W2012019322A5068472097 @default.
- W2012019322 hasAuthorship W2012019322A5070865626 @default.
- W2012019322 hasConcept C115624301 @default.
- W2012019322 hasConcept C120882062 @default.
- W2012019322 hasConcept C121332964 @default.
- W2012019322 hasConcept C12554922 @default.
- W2012019322 hasConcept C142724271 @default.
- W2012019322 hasConcept C185592680 @default.
- W2012019322 hasConcept C192157962 @default.
- W2012019322 hasConcept C2778370115 @default.
- W2012019322 hasConcept C37243968 @default.
- W2012019322 hasConcept C39519442 @default.
- W2012019322 hasConcept C41625074 @default.
- W2012019322 hasConcept C43617362 @default.
- W2012019322 hasConcept C50670333 @default.
- W2012019322 hasConcept C55493867 @default.
- W2012019322 hasConcept C71924100 @default.
- W2012019322 hasConcept C8010536 @default.
- W2012019322 hasConcept C86803240 @default.
- W2012019322 hasConcept C97355855 @default.
- W2012019322 hasConceptScore W2012019322C115624301 @default.
- W2012019322 hasConceptScore W2012019322C120882062 @default.
- W2012019322 hasConceptScore W2012019322C121332964 @default.
- W2012019322 hasConceptScore W2012019322C12554922 @default.
- W2012019322 hasConceptScore W2012019322C142724271 @default.
- W2012019322 hasConceptScore W2012019322C185592680 @default.
- W2012019322 hasConceptScore W2012019322C192157962 @default.
- W2012019322 hasConceptScore W2012019322C2778370115 @default.
- W2012019322 hasConceptScore W2012019322C37243968 @default.
- W2012019322 hasConceptScore W2012019322C39519442 @default.
- W2012019322 hasConceptScore W2012019322C41625074 @default.
- W2012019322 hasConceptScore W2012019322C43617362 @default.
- W2012019322 hasConceptScore W2012019322C50670333 @default.
- W2012019322 hasConceptScore W2012019322C55493867 @default.
- W2012019322 hasConceptScore W2012019322C71924100 @default.
- W2012019322 hasConceptScore W2012019322C8010536 @default.
- W2012019322 hasConceptScore W2012019322C86803240 @default.
- W2012019322 hasConceptScore W2012019322C97355855 @default.
- W2012019322 hasLocation W20120193221 @default.
- W2012019322 hasLocation W20120193222 @default.
- W2012019322 hasOpenAccess W2012019322 @default.
- W2012019322 hasPrimaryLocation W20120193221 @default.
- W2012019322 hasRelatedWork W1362500 @default.
- W2012019322 hasRelatedWork W1515614147 @default.
- W2012019322 hasRelatedWork W2026709799 @default.
- W2012019322 hasRelatedWork W2088079826 @default.
- W2012019322 hasRelatedWork W2092842253 @default.
- W2012019322 hasRelatedWork W2121036626 @default.
- W2012019322 hasRelatedWork W2128024327 @default.
- W2012019322 hasRelatedWork W2138556058 @default.
- W2012019322 hasRelatedWork W2512087541 @default.
- W2012019322 hasRelatedWork W2572592638 @default.
- W2012019322 isParatext "false" @default.
- W2012019322 isRetracted "false" @default.
- W2012019322 magId "2012019322" @default.
- W2012019322 workType "article" @default.