FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012019968> ?p ?o ?g. }

• W2012019968 endingPage "94" @default.
• W2012019968 startingPage "85" @default.
• W2012019968 abstract "Replicating episomal vectors (REV) are in principle able to provide long-term transgene expression in the absence of integration into the target cell genome. The scaffold/matrix attachment region (S/MAR) located 5′ of the human β-interferon gene (IFNB1) has been shown to confer a stable episomal replication and retention function within plasmid vectors when stably transfected and selected in mammalian cells. The minimal requirement for the IFNB1 S/MAR to function in DNA replication and episomal retention is transcription through this element. We used the erythroid β-globin locus control region-β-globin gene (βLCR-HBB) microlocus cassette as a model to assess tissue-specific expression from within an IFNB1 S/MAR-based plasmid REV. The βLCR-HBB plus S/MAR combination constructs provided either high or low levels of transcription through the S/MAR element. Our results show that the βLCR-HBB microlocus is able to reproducibly and stably express at full physiological levels on an episome copy number basis. In addition, our data show that even low levels of transcription from βLCR-HBB through the S/MAR element are sufficient to allow efficient episomal replication and retention. These data provide the principles upon which generic and flexible expression cassette-S/MAR-based REVs can be designed for a wide range of applications." @default.
• W2012019968 created "2016-06-24" @default.
• W2012019968 creator A5006824315 @default.
• W2012019968 creator A5015256804 @default.
• W2012019968 creator A5022832176 @default.
• W2012019968 creator A5029573639 @default.
• W2012019968 creator A5046834027 @default.
• W2012019968 date "2009-08-01" @default.
• W2012019968 modified "2023-10-01" @default.
• W2012019968 title "Physiological levels of HBB transgene expression from S/MAR element-based replicating episomal vectors" @default.
• W2012019968 cites W1484529414 @default.
• W2012019968 cites W1496334793 @default.
• W2012019968 cites W1591316509 @default.
• W2012019968 cites W1595583901 @default.
• W2012019968 cites W173196067 @default.
• W2012019968 cites W1965118572 @default.
• W2012019968 cites W1967446284 @default.
• W2012019968 cites W1968034459 @default.
• W2012019968 cites W1988904557 @default.
• W2012019968 cites W1996579924 @default.
• W2012019968 cites W2000397880 @default.
• W2012019968 cites W2002096007 @default.
• W2012019968 cites W2015006660 @default.
• W2012019968 cites W2023447778 @default.
• W2012019968 cites W2040583957 @default.
• W2012019968 cites W2045682863 @default.
• W2012019968 cites W2049109647 @default.
• W2012019968 cites W2049610944 @default.
• W2012019968 cites W2050206304 @default.
• W2012019968 cites W2051915898 @default.
• W2012019968 cites W2052494348 @default.
• W2012019968 cites W2055075101 @default.
• W2012019968 cites W2057037996 @default.
• W2012019968 cites W2062420521 @default.
• W2012019968 cites W2066914764 @default.
• W2012019968 cites W2067065069 @default.
• W2012019968 cites W2070196639 @default.
• W2012019968 cites W2070519686 @default.
• W2012019968 cites W2072295407 @default.
• W2012019968 cites W2092668266 @default.
• W2012019968 cites W2105041057 @default.
• W2012019968 cites W2114752899 @default.
• W2012019968 cites W2119080072 @default.
• W2012019968 cites W2126527023 @default.
• W2012019968 cites W2141340108 @default.
• W2012019968 cites W2147547112 @default.
• W2012019968 cites W2155254243 @default.
• W2012019968 cites W2169994979 @default.
• W2012019968 cites W2170043976 @default.
• W2012019968 cites W2334152511 @default.
• W2012019968 cites W240565591 @default.
• W2012019968 doi "https://doi.org/10.1016/j.jbiotec.2009.06.018" @default.
• W2012019968 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19559736" @default.
• W2012019968 hasPublicationYear "2009" @default.
• W2012019968 type Work @default.
• W2012019968 sameAs 2012019968 @default.
• W2012019968 citedByCount "19" @default.
• W2012019968 countsByYear W20120199682012 @default.
• W2012019968 countsByYear W20120199682013 @default.
• W2012019968 countsByYear W20120199682014 @default.
• W2012019968 countsByYear W20120199682016 @default.
• W2012019968 countsByYear W20120199682017 @default.
• W2012019968 countsByYear W20120199682018 @default.
• W2012019968 countsByYear W20120199682019 @default.
• W2012019968 countsByYear W20120199682023 @default.
• W2012019968 crossrefType "journal-article" @default.
• W2012019968 hasAuthorship W2012019968A5006824315 @default.
• W2012019968 hasAuthorship W2012019968A5015256804 @default.
• W2012019968 hasAuthorship W2012019968A5022832176 @default.
• W2012019968 hasAuthorship W2012019968A5029573639 @default.
• W2012019968 hasAuthorship W2012019968A5046834027 @default.
• W2012019968 hasConcept C100012643 @default.
• W2012019968 hasConcept C10147152 @default.
• W2012019968 hasConcept C101762097 @default.
• W2012019968 hasConcept C102230213 @default.
• W2012019968 hasConcept C104317684 @default.
• W2012019968 hasConcept C138885662 @default.
• W2012019968 hasConcept C150194340 @default.
• W2012019968 hasConcept C153911025 @default.
• W2012019968 hasConcept C167227067 @default.
• W2012019968 hasConcept C179926584 @default.
• W2012019968 hasConcept C22744801 @default.
• W2012019968 hasConcept C2776650774 @default.
• W2012019968 hasConcept C39981086 @default.
• W2012019968 hasConcept C40767141 @default.
• W2012019968 hasConcept C41895202 @default.
• W2012019968 hasConcept C54355233 @default.
• W2012019968 hasConcept C56262557 @default.
• W2012019968 hasConcept C73573662 @default.
• W2012019968 hasConcept C86803240 @default.
• W2012019968 hasConcept C92087593 @default.
• W2012019968 hasConcept C95444343 @default.
• W2012019968 hasConceptScore W2012019968C100012643 @default.
• W2012019968 hasConceptScore W2012019968C10147152 @default.
• W2012019968 hasConceptScore W2012019968C101762097 @default.
• W2012019968 hasConceptScore W2012019968C102230213 @default.
• W2012019968 hasConceptScore W2012019968C104317684 @default.
• W2012019968 hasConceptScore W2012019968C138885662 @default.

• next