FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012020905> ?p ?o ?g. }

• W2012020905 endingPage "4472" @default.
• W2012020905 startingPage "4467" @default.
• W2012020905 abstract "The misfolding of serpins is linked to several genetic disorders including emphysema, thrombosis, and dementia. During folding, inhibitory serpins are kinetically trapped in a metastable state in which a stretch of residues near the C terminus of the molecule are exposed to solvent as a flexible loop (the reactive center loop). When they inhibit target proteases, serpins transition to a stable state in which the reactive center loop forms part of a six-stranded β-sheet. Here, we use hydrogen-deuterium exchange mass spectrometry to monitor region-specific folding of the canonical serpin human α(1)-antitrypsin (α(1)-AT). We find large differences in the folding kinetics of different regions. A key region in the metastable → stable transition, β-strand 5A, shows a lag phase of nearly 350 s. In contrast, the B-C barrel region shows no lag phase and the incorporation of the C-terminal residues into β-sheets B and C is largely complete before the center of β-sheet A begins to fold. We propose this as the mechanism for trapping α(1)-AT in a metastable form. Additionally, this separation of timescales in the folding of different regions suggests a mechanism by which α(1)-AT avoids polymerization during folding." @default.
• W2012020905 created "2016-06-24" @default.
• W2012020905 creator A5030611971 @default.
• W2012020905 creator A5039038918 @default.
• W2012020905 creator A5062757453 @default.
• W2012020905 date "2012-03-05" @default.
• W2012020905 modified "2023-10-12" @default.
• W2012020905 title "Folding mechanism of the metastable serpin <i>α</i> ₁ -antitrypsin" @default.
• W2012020905 cites W1555987236 @default.
• W2012020905 cites W1583012020 @default.
• W2012020905 cites W1974229917 @default.
• W2012020905 cites W1977954648 @default.
• W2012020905 cites W1995655166 @default.
• W2012020905 cites W1999286331 @default.
• W2012020905 cites W2004171397 @default.
• W2012020905 cites W2005533639 @default.
• W2012020905 cites W2013474205 @default.
• W2012020905 cites W2058226155 @default.
• W2012020905 cites W2073457036 @default.
• W2012020905 cites W2084601926 @default.
• W2012020905 cites W2094499644 @default.
• W2012020905 cites W2095505843 @default.
• W2012020905 cites W2105400502 @default.
• W2012020905 cites W2115824900 @default.
• W2012020905 cites W2122492374 @default.
• W2012020905 cites W2123496533 @default.
• W2012020905 cites W2133604915 @default.
• W2012020905 cites W2163209426 @default.
• W2012020905 cites W2169225273 @default.
• W2012020905 doi "https://doi.org/10.1073/pnas.1109125109" @default.
• W2012020905 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3311335" @default.
• W2012020905 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22392975" @default.
• W2012020905 hasPublicationYear "2012" @default.
• W2012020905 type Work @default.
• W2012020905 sameAs 2012020905 @default.
• W2012020905 citedByCount "63" @default.
• W2012020905 countsByYear W20120209052012 @default.
• W2012020905 countsByYear W20120209052013 @default.
• W2012020905 countsByYear W20120209052014 @default.
• W2012020905 countsByYear W20120209052016 @default.
• W2012020905 countsByYear W20120209052017 @default.
• W2012020905 countsByYear W20120209052018 @default.
• W2012020905 countsByYear W20120209052019 @default.
• W2012020905 countsByYear W20120209052020 @default.
• W2012020905 countsByYear W20120209052021 @default.
• W2012020905 countsByYear W20120209052022 @default.
• W2012020905 countsByYear W20120209052023 @default.
• W2012020905 crossrefType "journal-article" @default.
• W2012020905 hasAuthorship W2012020905A5030611971 @default.
• W2012020905 hasAuthorship W2012020905A5039038918 @default.
• W2012020905 hasAuthorship W2012020905A5062757453 @default.
• W2012020905 hasBestOaLocation W20120209051 @default.
• W2012020905 hasConcept C104317684 @default.
• W2012020905 hasConcept C119599485 @default.
• W2012020905 hasConcept C121332964 @default.
• W2012020905 hasConcept C12554922 @default.
• W2012020905 hasConcept C127413603 @default.
• W2012020905 hasConcept C148898269 @default.
• W2012020905 hasConcept C162203774 @default.
• W2012020905 hasConcept C178790620 @default.
• W2012020905 hasConcept C185592680 @default.
• W2012020905 hasConcept C204328495 @default.
• W2012020905 hasConcept C2776545253 @default.
• W2012020905 hasConcept C2778965386 @default.
• W2012020905 hasConcept C46449900 @default.
• W2012020905 hasConcept C55493867 @default.
• W2012020905 hasConcept C62520636 @default.
• W2012020905 hasConcept C71240020 @default.
• W2012020905 hasConcept C8010536 @default.
• W2012020905 hasConcept C86803240 @default.
• W2012020905 hasConcept C89464430 @default.
• W2012020905 hasConceptScore W2012020905C104317684 @default.
• W2012020905 hasConceptScore W2012020905C119599485 @default.
• W2012020905 hasConceptScore W2012020905C121332964 @default.
• W2012020905 hasConceptScore W2012020905C12554922 @default.
• W2012020905 hasConceptScore W2012020905C127413603 @default.
• W2012020905 hasConceptScore W2012020905C148898269 @default.
• W2012020905 hasConceptScore W2012020905C162203774 @default.
• W2012020905 hasConceptScore W2012020905C178790620 @default.
• W2012020905 hasConceptScore W2012020905C185592680 @default.
• W2012020905 hasConceptScore W2012020905C204328495 @default.
• W2012020905 hasConceptScore W2012020905C2776545253 @default.
• W2012020905 hasConceptScore W2012020905C2778965386 @default.
• W2012020905 hasConceptScore W2012020905C46449900 @default.
• W2012020905 hasConceptScore W2012020905C55493867 @default.
• W2012020905 hasConceptScore W2012020905C62520636 @default.
• W2012020905 hasConceptScore W2012020905C71240020 @default.
• W2012020905 hasConceptScore W2012020905C8010536 @default.
• W2012020905 hasConceptScore W2012020905C86803240 @default.
• W2012020905 hasConceptScore W2012020905C89464430 @default.
• W2012020905 hasIssue "12" @default.
• W2012020905 hasLocation W20120209051 @default.
• W2012020905 hasLocation W20120209052 @default.
• W2012020905 hasLocation W20120209053 @default.
• W2012020905 hasLocation W20120209054 @default.
• W2012020905 hasOpenAccess W2012020905 @default.
• W2012020905 hasPrimaryLocation W20120209051 @default.
• W2012020905 hasRelatedWork W1969607952 @default.

• next