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• W2012021007 abstract "Growth hormone (GH) has been shown to stimulate T cell development. However, its mechanisms of action on the peripheral T cell pool remain unknown. To address this question, intrathymic injection of GH in combination with fluorescein isothiocyanate (FITC) was used to assess the effects of GH on T cell trafficking from the thymus to the periphery. GH promoted a significant increase in the percentage and differential distribution of thymic CD4+CD8-FITC+ cells in secondary lymphoid organs. A significantly higher percentage of CD4+CD8-FITC+ cells was observed in the lymph nodes, while a relative decrease of these cells was found in the spleen. Moreover, we verified that GH treatment resulted in increased numbers of CD62L+CD4+CD8-FITC+ T cells in the lymph nodes, while the same treatment resulted in a decline in the percentage of VLA-6+CD4+CD8-FITC+ T cells in the spleen. Together, these findings suggest that GH is a potent immunoregulatory molecule which selectively stimulates the preferential homing of CD4+CD8- thymic emigrants to the subcutaneous lymph nodes possibly via the differential expression of CD62L and VLA-6." @default.
• W2012021007 created "2016-06-24" @default.
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• W2012021007 date "2004-01-01" @default.
• W2012021007 modified "2023-09-26" @default.
• W2012021007 title "Growth Hormone Stimulates the Selective Trafficking of Thymic CD4+CD8– Emigrants to Peripheral Lymphoid Organs" @default.
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• W2012021007 doi "https://doi.org/10.1159/000079410" @default.
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