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- W2012021102 abstract "Ewing's Sarcoma Oncogene (ews) on chromosome 22q12 is encoding a ubiquitously expressed RNA-binding protein (EWS) with unknown function that is target of tumor-specific chromosomal translocations in Ewing's sarcoma family of tumors. A model of transcription complex was proposed in which the heterodimer Rpb4/7 binds to EAD, connecting it to Core RNA Pol II. The DNA-binding domain, provided by EFP, is bound to the promoter. Rpb4/7 binds RNA, stabilizing the transcription complex. The complex Rpb4/7 can stabilize the preinitiation complexes by converting the conformation of RNA Pol II. EWS may change its conformation, so that NTD becomes accessible. Two different mechanisms of interaction between EWS and RNA Pol II are proposed: (I) an intermolecular EWS-EWS interaction between two molecules, pushing conformation from closed to open state, or (II) an intramolecular interaction inside the molecule of EWS, pushing conformation of the molecule from closed to open state. The modified forms of EWS may interact with Pol II subunits hsRpb5 and hsRpb7. The EWS and EFPs binding partners are described schematically in a model, an attempt to link the transcription with the splicing. The proposed model helps to understand the functional molecular interactions in cancer, to find new partners and ways to treat cancer." @default.
- W2012021102 created "2016-06-24" @default.
- W2012021102 creator A5038793902 @default.
- W2012021102 date "2015-01-01" @default.
- W2012021102 modified "2023-09-27" @default.
- W2012021102 title "Structure-Function Based Molecular Relationships in Ewing’s Sarcoma" @default.
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- W2012021102 doi "https://doi.org/10.1155/2015/798426" @default.