FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012022368> ?p ?o ?g. }

• W2012022368 endingPage "1995" @default.
• W2012022368 startingPage "1988" @default.
• W2012022368 abstract "RNA editing is a mitochondrial transcript maturation process which evolved in kinetoplastid protozoa. It entails the insertion and deletion of exclusively uridine nucleotides directed by gRNAs into pre-mRNAs. Other participating components are not currently known. The aim of this study was to identify mitochondrial proteins that are in direct physical contact with gRNAs thereby possibly involved in the editing reaction. At low monovalent cation concentration (30 mM KCl) 8 polypeptides with apparent molecular weights ranging from 124 to 9 kDa specifically cross-linked to gRNAs. Three of the proteins, 90, 21, and 9 kDa in size, were able to bind at higher salt concentrations (> or = 100 mM) indicating an enhanced affinity to the gRNA molecules. No cross-links were identified at > or = 250 mM KCl. Four gRNAs, specific for different editing domains of the ATPase 6 and ND7 pre-mRNAs, were in contact with the same set of mitochondrial polypeptides suggesting the assembly of an identical RNP complex that does not include pre-mRNA molecules. The binding of the 90 kDa protein was sensitive to the presence of U-nucleotides at the 3'-end of the gRNAs and could specifically be blocked by modifying free sulfhydryl groups. The interaction with the 124 kDa polypeptide was inhibited by vanadyl ribonucleosides, implicating a role for 2', 3' hydroxyl groups in the gRNA-protein interaction." @default.
• W2012022368 created "2016-06-24" @default.
• W2012022368 creator A5022922032 @default.
• W2012022368 creator A5027478639 @default.
• W2012022368 creator A5046125174 @default.
• W2012022368 creator A5060803600 @default.
• W2012022368 creator A5063814653 @default.
• W2012022368 date "1994-01-01" @default.
• W2012022368 modified "2023-09-23" @default.
• W2012022368 title "Different<i>Trypanosoma brucei</i>guide RNA molecules associate with an identical complement of mitochondrial proteins<i>in vitro</i>" @default.
• W2012022368 cites W1004390544 @default.
• W2012022368 cites W1044509411 @default.
• W2012022368 cites W1524970720 @default.
• W2012022368 cites W1534643095 @default.
• W2012022368 cites W1607616091 @default.
• W2012022368 cites W1887878037 @default.
• W2012022368 cites W1934766143 @default.
• W2012022368 cites W1969757078 @default.
• W2012022368 cites W1981419683 @default.
• W2012022368 cites W1982111580 @default.
• W2012022368 cites W1993742413 @default.
• W2012022368 cites W2007040484 @default.
• W2012022368 cites W2009310436 @default.
• W2012022368 cites W2018289835 @default.
• W2012022368 cites W2019081464 @default.
• W2012022368 cites W2022472275 @default.
• W2012022368 cites W2028505310 @default.
• W2012022368 cites W2032558977 @default.
• W2012022368 cites W2035230667 @default.
• W2012022368 cites W2037136121 @default.
• W2012022368 cites W2084025668 @default.
• W2012022368 cites W2084748156 @default.
• W2012022368 cites W2086300581 @default.
• W2012022368 cites W2087862352 @default.
• W2012022368 cites W2093673843 @default.
• W2012022368 cites W2100837269 @default.
• W2012022368 cites W2103598384 @default.
• W2012022368 cites W2126114647 @default.
• W2012022368 cites W2128635872 @default.
• W2012022368 cites W2128972342 @default.
• W2012022368 cites W2264429446 @default.
• W2012022368 cites W2314959220 @default.
• W2012022368 cites W2327253208 @default.
• W2012022368 cites W70041852 @default.
• W2012022368 doi "https://doi.org/10.1093/nar/22.11.1988" @default.
• W2012022368 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/308111" @default.
• W2012022368 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8029004" @default.
• W2012022368 hasPublicationYear "1994" @default.
• W2012022368 type Work @default.
• W2012022368 sameAs 2012022368 @default.
• W2012022368 citedByCount "49" @default.
• W2012022368 countsByYear W20120223682012 @default.
• W2012022368 countsByYear W20120223682013 @default.
• W2012022368 countsByYear W20120223682014 @default.
• W2012022368 crossrefType "journal-article" @default.
• W2012022368 hasAuthorship W2012022368A5022922032 @default.
• W2012022368 hasAuthorship W2012022368A5027478639 @default.
• W2012022368 hasAuthorship W2012022368A5046125174 @default.
• W2012022368 hasAuthorship W2012022368A5060803600 @default.
• W2012022368 hasAuthorship W2012022368A5063814653 @default.
• W2012022368 hasBestOaLocation W20120223682 @default.
• W2012022368 hasConcept C104317684 @default.
• W2012022368 hasConcept C132455925 @default.
• W2012022368 hasConcept C21786251 @default.
• W2012022368 hasConcept C2779502636 @default.
• W2012022368 hasConcept C512185932 @default.
• W2012022368 hasConcept C55493867 @default.
• W2012022368 hasConcept C67705224 @default.
• W2012022368 hasConcept C86803240 @default.
• W2012022368 hasConcept C95444343 @default.
• W2012022368 hasConcept C97702854 @default.
• W2012022368 hasConcept C98108389 @default.
• W2012022368 hasConceptScore W2012022368C104317684 @default.
• W2012022368 hasConceptScore W2012022368C132455925 @default.
• W2012022368 hasConceptScore W2012022368C21786251 @default.
• W2012022368 hasConceptScore W2012022368C2779502636 @default.
• W2012022368 hasConceptScore W2012022368C512185932 @default.
• W2012022368 hasConceptScore W2012022368C55493867 @default.
• W2012022368 hasConceptScore W2012022368C67705224 @default.
• W2012022368 hasConceptScore W2012022368C86803240 @default.
• W2012022368 hasConceptScore W2012022368C95444343 @default.
• W2012022368 hasConceptScore W2012022368C97702854 @default.
• W2012022368 hasConceptScore W2012022368C98108389 @default.
• W2012022368 hasIssue "11" @default.
• W2012022368 hasLocation W20120223681 @default.
• W2012022368 hasLocation W20120223682 @default.
• W2012022368 hasLocation W20120223683 @default.
• W2012022368 hasLocation W20120223684 @default.
• W2012022368 hasOpenAccess W2012022368 @default.
• W2012022368 hasPrimaryLocation W20120223681 @default.
• W2012022368 hasRelatedWork W1767538696 @default.
• W2012022368 hasRelatedWork W1826797671 @default.
• W2012022368 hasRelatedWork W1987829323 @default.
• W2012022368 hasRelatedWork W1994441110 @default.
• W2012022368 hasRelatedWork W2013022956 @default.
• W2012022368 hasRelatedWork W2048571001 @default.
• W2012022368 hasRelatedWork W2109930513 @default.
• W2012022368 hasRelatedWork W2137693843 @default.

• next