Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012024022> ?p ?o ?g. }
Showing items 1 to 39 of
39
with 100 items per page.
- W2012024022 abstract "The causal relationship between protein structural features and conformational dynamics is difficult to isolate experimentally because even seemingly small perturbations, such as point mutations, can simultaneously alter many physical properties of proteins. Using molecular dynamics simulation trajectories for a series of point mutations at a single solvent-exposed position on the protein GB1, for which experimental NMR spin relaxation data also are available [1], effects of various types of inter-residue interactions are isolated via a graph-theory-based approach to causal modeling [2] previously applied in the biological sciences mainly to functional MRI studies [3] and genomics [4]. This approach produces directed acyclic graphs (DAGs) in which protein structural features such as hydrogen bonds, inter-residue contacts, and order parameters are encoded as nodes; the presence of an edge in the graph implies a causal relationship between features and the directionality of the edge implies the direction of causation.[1] Mayer, KL et al. (2003). Nat. Struct. Biol. 10: 962-965.[2] Pearl, J. (2000). Cambridge University Press, London; Pearl, J. (2009). Statistics Surveys. 3:96-146; Spirtes et al. (2000). MIT Press, Cambridge.[3] Eichler, M. (2005). Phil. Trans. R. Soc. B. 360(1457): 953-967.[4] Maathius, MH et al. (2009). Ann. Stat. 37(6A): 3133-3164." @default.
- W2012024022 created "2016-06-24" @default.
- W2012024022 creator A5014635524 @default.
- W2012024022 creator A5055240763 @default.
- W2012024022 date "2010-01-01" @default.
- W2012024022 modified "2023-09-26" @default.
- W2012024022 title "Graphical Causal Modeling of Protein Structural and Dynamical Features" @default.
- W2012024022 doi "https://doi.org/10.1016/j.bpj.2009.12.3069" @default.
- W2012024022 hasPublicationYear "2010" @default.
- W2012024022 type Work @default.
- W2012024022 sameAs 2012024022 @default.
- W2012024022 citedByCount "0" @default.
- W2012024022 crossrefType "journal-article" @default.
- W2012024022 hasAuthorship W2012024022A5014635524 @default.
- W2012024022 hasAuthorship W2012024022A5055240763 @default.
- W2012024022 hasBestOaLocation W20120240221 @default.
- W2012024022 hasConcept C114614502 @default.
- W2012024022 hasConcept C121332964 @default.
- W2012024022 hasConcept C121864883 @default.
- W2012024022 hasConcept C185592680 @default.
- W2012024022 hasConcept C33923547 @default.
- W2012024022 hasConcept C70721500 @default.
- W2012024022 hasConcept C86803240 @default.
- W2012024022 hasConceptScore W2012024022C114614502 @default.
- W2012024022 hasConceptScore W2012024022C121332964 @default.
- W2012024022 hasConceptScore W2012024022C121864883 @default.
- W2012024022 hasConceptScore W2012024022C185592680 @default.
- W2012024022 hasConceptScore W2012024022C33923547 @default.
- W2012024022 hasConceptScore W2012024022C70721500 @default.
- W2012024022 hasConceptScore W2012024022C86803240 @default.
- W2012024022 hasLocation W20120240221 @default.
- W2012024022 hasOpenAccess W2012024022 @default.
- W2012024022 hasPrimaryLocation W20120240221 @default.
- W2012024022 hasRelatedWork W2082400747 @default.
- W2012024022 hasRelatedWork W3171977971 @default.
- W2012024022 isParatext "false" @default.
- W2012024022 isRetracted "false" @default.
- W2012024022 magId "2012024022" @default.
- W2012024022 workType "article" @default.