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• W2012027719 startingPage "133" @default.
• W2012027719 abstract "Mitochondrial encephalomyopathies are clinically and genetically heterogeneous disorders. External ophthalmoplegia is the most frequent symptom. Other frequently involved tissues and organs include the retina, heart, limb muscles, peripheral and central nervous system, inner ear and endocrine system. The diagnosis is based on the finding of elevated serum lactate, the characteristic histopathological changes in the muscle biopsy, and decreased activities of mitochondrial respiratory chain enzymes. In many cases, the underlying molecular defect in the mtDNA can be identified. The efficacy of pharmacological therapies (e.g., coenzyme Q) has not been established so far. Symptomatic ophthalmological treatment includes ptosis and strabismus surgery. Early cardiac pacemaker implantation may be life-saving." @default.
• W2012027719 created "2016-06-24" @default.
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• W2012027719 creator A5088598448 @default.
• W2012027719 date "2005-01-01" @default.
• W2012027719 modified "2023-10-12" @default.
• W2012027719 title "Update on Chronic Progressive External Ophthalmoplegia" @default.
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• W2012027719 doi "https://doi.org/10.1080/09273970500216432" @default.
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