FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012028111> ?p ?o ?g. }

• W2012028111 endingPage "708" @default.
• W2012028111 startingPage "701" @default.
• W2012028111 abstract "Abstract: A well-controlled local immune response is needed for recovery from CNS injury, and autoimmune T cells play a key role in mediating this response. Autoimmunity, at least in the context of the CNS, is the body's fighting force against self-derived destructive compounds, and “tolerance to self” (traditionally though mistakenly equated with nonresponsiveness) should be viewed as the ability to tolerate autoimmune responses without developing an autoimmune disease. This physiological repair mechanism is controlled by naturally occurring CD4+CD25+ regulatory T cells (Treg cells), with an on/off switch regulated by brain-derived compounds. We suggest that ongoing neurodegeneration after acute injuries results from insufficiency of the endogenous fighting force, and chronic neurodegenerative diseases reflect age-related deterioration of the body's two principal regulators: the central nervous system (CNS) and the immune system. If so, then the restoration or boosting of immune function might bridge the gap between such manifestations of CNS-related risk factors and the defensive capacity of the immune system. Boosting of peripheral immunity by the use of weak agonists of CNS self-antigens, might offer a promising potential therapy for different neurodegenerative conditions. This could be accomplished either by vaccination with a universal weak T cell-reactive antigen or with altered peptide ligands of self-antigens, or by weakening the suppressive effect of autoimmunity (e.g., by eliminating Treg cells). T cells that home to the damaged CNS might then help restore local homeostasis by controlling the local microglial response. Because neurodegenerative diseases possess common features (deriving from the local chaos), the same vaccine might protect against several different disorders associated with impaired motor, sensory, cognitive, or mental functions of the brain." @default.
• W2012028111 created "2016-06-24" @default.
• W2012028111 creator A5065834855 @default.
• W2012028111 creator A5088728393 @default.
• W2012028111 date "2005-06-01" @default.
• W2012028111 modified "2023-10-11" @default.
• W2012028111 title "Therapeutic T Cell-Based Vaccination for Neurodegenerative Disorders: The Role of CD4⁺CD25⁺Regulatory T Cells" @default.
• W2012028111 cites W1498554079 @default.
• W2012028111 cites W1547225066 @default.
• W2012028111 cites W1555564331 @default.
• W2012028111 cites W1581871973 @default.
• W2012028111 cites W1900649416 @default.
• W2012028111 cites W1964229968 @default.
• W2012028111 cites W1969557429 @default.
• W2012028111 cites W2002586153 @default.
• W2012028111 cites W2004241753 @default.
• W2012028111 cites W2014651619 @default.
• W2012028111 cites W2017605183 @default.
• W2012028111 cites W2021622667 @default.
• W2012028111 cites W2022362212 @default.
• W2012028111 cites W2022482220 @default.
• W2012028111 cites W2023990578 @default.
• W2012028111 cites W2031797110 @default.
• W2012028111 cites W2043290296 @default.
• W2012028111 cites W2047245436 @default.
• W2012028111 cites W2047357186 @default.
• W2012028111 cites W2051132773 @default.
• W2012028111 cites W2069560534 @default.
• W2012028111 cites W2071964449 @default.
• W2012028111 cites W2074364583 @default.
• W2012028111 cites W2083286809 @default.
• W2012028111 cites W2093110974 @default.
• W2012028111 cites W2098734841 @default.
• W2012028111 cites W2101230909 @default.
• W2012028111 cites W2101596476 @default.
• W2012028111 cites W2106181827 @default.
• W2012028111 cites W2107800314 @default.
• W2012028111 cites W2110939383 @default.
• W2012028111 cites W2112884626 @default.
• W2012028111 cites W2114866206 @default.
• W2012028111 cites W2116688247 @default.
• W2012028111 cites W2127148071 @default.
• W2012028111 cites W2142820307 @default.
• W2012028111 cites W2145358071 @default.
• W2012028111 cites W27333232 @default.
• W2012028111 cites W4234147211 @default.
• W2012028111 doi "https://doi.org/10.1196/annals.1361.114" @default.
• W2012028111 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16127010" @default.
• W2012028111 hasPublicationYear "2005" @default.
• W2012028111 type Work @default.
• W2012028111 sameAs 2012028111 @default.
• W2012028111 citedByCount "31" @default.
• W2012028111 countsByYear W20120281112012 @default.
• W2012028111 countsByYear W20120281112013 @default.
• W2012028111 countsByYear W20120281112014 @default.
• W2012028111 countsByYear W20120281112016 @default.
• W2012028111 countsByYear W20120281112017 @default.
• W2012028111 countsByYear W20120281112018 @default.
• W2012028111 crossrefType "journal-article" @default.
• W2012028111 hasAuthorship W2012028111A5065834855 @default.
• W2012028111 hasAuthorship W2012028111A5088728393 @default.
• W2012028111 hasConcept C142724271 @default.
• W2012028111 hasConcept C147483822 @default.
• W2012028111 hasConcept C169760540 @default.
• W2012028111 hasConcept C19317047 @default.
• W2012028111 hasConcept C203014093 @default.
• W2012028111 hasConcept C2776090121 @default.
• W2012028111 hasConcept C2776914184 @default.
• W2012028111 hasConcept C2776925932 @default.
• W2012028111 hasConcept C2777868816 @default.
• W2012028111 hasConcept C2778296632 @default.
• W2012028111 hasConcept C2779134260 @default.
• W2012028111 hasConcept C2780130043 @default.
• W2012028111 hasConcept C71924100 @default.
• W2012028111 hasConcept C79484868 @default.
• W2012028111 hasConcept C86803240 @default.
• W2012028111 hasConcept C87753298 @default.
• W2012028111 hasConcept C8891405 @default.
• W2012028111 hasConceptScore W2012028111C142724271 @default.
• W2012028111 hasConceptScore W2012028111C147483822 @default.
• W2012028111 hasConceptScore W2012028111C169760540 @default.
• W2012028111 hasConceptScore W2012028111C19317047 @default.
• W2012028111 hasConceptScore W2012028111C203014093 @default.
• W2012028111 hasConceptScore W2012028111C2776090121 @default.
• W2012028111 hasConceptScore W2012028111C2776914184 @default.
• W2012028111 hasConceptScore W2012028111C2776925932 @default.
• W2012028111 hasConceptScore W2012028111C2777868816 @default.
• W2012028111 hasConceptScore W2012028111C2778296632 @default.
• W2012028111 hasConceptScore W2012028111C2779134260 @default.
• W2012028111 hasConceptScore W2012028111C2780130043 @default.
• W2012028111 hasConceptScore W2012028111C71924100 @default.
• W2012028111 hasConceptScore W2012028111C79484868 @default.
• W2012028111 hasConceptScore W2012028111C86803240 @default.
• W2012028111 hasConceptScore W2012028111C87753298 @default.
• W2012028111 hasConceptScore W2012028111C8891405 @default.
• W2012028111 hasIssue "1" @default.
• W2012028111 hasLocation W20120281111 @default.
• W2012028111 hasLocation W20120281112 @default.

• next