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• W2012028367 abstract "Accurate modeling of arterial response to physiological or pathological loads may shed light on the processes leading to initiation and progression of a number of vascular diseases and may serve as a tool for prediction and diagnosis. In this study, a microstructure based hyperelastic constitutive model is developed for passive media of porcine coronary arteries. The most general model contains 12 independent parameters representing the three-dimensional inner fibrous structure of the media and includes the effects of residual stresses and osmotic swelling. Parameter estimation and model validation were based on mechanical data of porcine left anterior descending (LAD) media under radial inflation, axial extension, and twist tests. The results show that a reduced four parameter model is sufficient to reliably predict the passive mechanical properties. These parameters represent the stiffness and the helical orientation of each lamellae fiber and the stiffness of the interlamellar struts interconnecting these lamellae. Other structural features, such as orientational distribution of helical fibers and anisotropy of the interlamellar network, as well as possible transmural distribution of structural features, were found to have little effect on the global media mechanical response. It is shown that the model provides good predictions of the LAD media twist response based on parameters estimated from only biaxial tests of inflation and extension. In addition, good predictive capabilities are demonstrated for the model behavior at high axial stretch ratio based on data of law stretches." @default.
• W2012028367 created "2016-06-24" @default.
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• W2012028367 date "2011-02-07" @default.
• W2012028367 modified "2023-10-06" @default.
• W2012028367 title "Experimentally Validated Microstructural 3D Constitutive Model of Coronary Arterial Media" @default.
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• W2012028367 doi "https://doi.org/10.1115/1.4003324" @default.
• W2012028367 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3249663" @default.
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