FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012029166> ?p ?o ?g. }

• W2012029166 endingPage "401" @default.
• W2012029166 startingPage "396" @default.
• W2012029166 abstract "In elderly individuals high levels of interleukin-1β (IL-1β) in the brain have been implicated in infection-related behavioral pathologies but this has not been directly tested. Therefore, the current study investigated if sickness behavior in aged animals elicited by peripheral injection of lipopolysaccharide (LPS) is mediated through central IL-1β. Adult and aged mice were injected intracerebroventricularly with either saline or IL-1ra (4 μg) immediately prior to intraperitoneal administration of saline or LPS (10 μg) and locomotor and social behaviors were assessed. As anticipated, LPS depressed locomotor activity and social behavior in both adult and aged mice but the behavioral deficits were markedly greater in the aged at 24 h. Pretreatment with IL-1ra did not affect LPS-induced sickness behavior in adults; however, in aged mice IL-1ra attenuated LPS-induced sickness behavior, restoring it to the level exhibited by young adults. Twenty-four hours post-injection hippocampal and hypothalamic tissues were collected to determine IL-1β mRNA expression. Neither LPS nor IL-1ra affected IL-1β mRNA levels in adults, presumably because any effect of LPS had dissipated by 24 h. In contrast, IL-1β mRNA was markedly higher in aged mice 24 h after LPS, and prior treatment with IL-1ra either blocked or attenuated this effect in the hippocampus and hypothalamus, respectively. Taken together these data provide the first direct evidence that central IL-1β is responsible for the severe sickness behavior observed in aged animals after LPS treatment. Thus, inhibiting the central actions of IL-1β may be useful for minimizing behavioral complications in older individuals with an infection." @default.
• W2012029166 created "2016-06-24" @default.
• W2012029166 creator A5028274783 @default.
• W2012029166 creator A5038827888 @default.
• W2012029166 date "2009-03-01" @default.
• W2012029166 modified "2023-10-14" @default.
• W2012029166 title "Central inhibition of interleukin-1β ameliorates sickness behavior in aged mice" @default.
• W2012029166 cites W1966985410 @default.
• W2012029166 cites W1972447837 @default.
• W2012029166 cites W1991740724 @default.
• W2012029166 cites W1996826305 @default.
• W2012029166 cites W1997862123 @default.
• W2012029166 cites W2001809220 @default.
• W2012029166 cites W2008329588 @default.
• W2012029166 cites W2008638854 @default.
• W2012029166 cites W2026592886 @default.
• W2012029166 cites W2031312655 @default.
• W2012029166 cites W2045040998 @default.
• W2012029166 cites W2054594878 @default.
• W2012029166 cites W2061941265 @default.
• W2012029166 cites W2062790940 @default.
• W2012029166 cites W2071394393 @default.
• W2012029166 cites W2071672111 @default.
• W2012029166 cites W2071698914 @default.
• W2012029166 cites W2076324223 @default.
• W2012029166 cites W2078315765 @default.
• W2012029166 cites W2079756902 @default.
• W2012029166 cites W2087007260 @default.
• W2012029166 cites W2093413494 @default.
• W2012029166 cites W2097456438 @default.
• W2012029166 cites W2099555137 @default.
• W2012029166 cites W2103369019 @default.
• W2012029166 cites W2118118182 @default.
• W2012029166 cites W2126795224 @default.
• W2012029166 cites W2140087978 @default.
• W2012029166 cites W2154653323 @default.
• W2012029166 cites W3149326883 @default.
• W2012029166 doi "https://doi.org/10.1016/j.bbi.2008.12.008" @default.
• W2012029166 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2704385" @default.
• W2012029166 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19152833" @default.
• W2012029166 hasPublicationYear "2009" @default.
• W2012029166 type Work @default.
• W2012029166 sameAs 2012029166 @default.
• W2012029166 citedByCount "74" @default.
• W2012029166 countsByYear W20120291662012 @default.
• W2012029166 countsByYear W20120291662013 @default.
• W2012029166 countsByYear W20120291662014 @default.
• W2012029166 countsByYear W20120291662015 @default.
• W2012029166 countsByYear W20120291662016 @default.
• W2012029166 countsByYear W20120291662017 @default.
• W2012029166 countsByYear W20120291662018 @default.
• W2012029166 countsByYear W20120291662019 @default.
• W2012029166 countsByYear W20120291662020 @default.
• W2012029166 countsByYear W20120291662021 @default.
• W2012029166 countsByYear W20120291662022 @default.
• W2012029166 countsByYear W20120291662023 @default.
• W2012029166 crossrefType "journal-article" @default.
• W2012029166 hasAuthorship W2012029166A5028274783 @default.
• W2012029166 hasAuthorship W2012029166A5038827888 @default.
• W2012029166 hasBestOaLocation W20120291662 @default.
• W2012029166 hasConcept C126322002 @default.
• W2012029166 hasConcept C134018914 @default.
• W2012029166 hasConcept C138906646 @default.
• W2012029166 hasConcept C148762608 @default.
• W2012029166 hasConcept C2777003273 @default.
• W2012029166 hasConcept C2777397205 @default.
• W2012029166 hasConcept C2778690821 @default.
• W2012029166 hasConcept C2778754761 @default.
• W2012029166 hasConcept C2781161787 @default.
• W2012029166 hasConcept C71924100 @default.
• W2012029166 hasConcept C74172505 @default.
• W2012029166 hasConceptScore W2012029166C126322002 @default.
• W2012029166 hasConceptScore W2012029166C134018914 @default.
• W2012029166 hasConceptScore W2012029166C138906646 @default.
• W2012029166 hasConceptScore W2012029166C148762608 @default.
• W2012029166 hasConceptScore W2012029166C2777003273 @default.
• W2012029166 hasConceptScore W2012029166C2777397205 @default.
• W2012029166 hasConceptScore W2012029166C2778690821 @default.
• W2012029166 hasConceptScore W2012029166C2778754761 @default.
• W2012029166 hasConceptScore W2012029166C2781161787 @default.
• W2012029166 hasConceptScore W2012029166C71924100 @default.
• W2012029166 hasConceptScore W2012029166C74172505 @default.
• W2012029166 hasIssue "3" @default.
• W2012029166 hasLocation W20120291661 @default.
• W2012029166 hasLocation W20120291662 @default.
• W2012029166 hasLocation W20120291663 @default.
• W2012029166 hasLocation W20120291664 @default.
• W2012029166 hasOpenAccess W2012029166 @default.
• W2012029166 hasPrimaryLocation W20120291661 @default.
• W2012029166 hasRelatedWork W111804031 @default.
• W2012029166 hasRelatedWork W1969773497 @default.
• W2012029166 hasRelatedWork W2061953809 @default.
• W2012029166 hasRelatedWork W2087562989 @default.
• W2012029166 hasRelatedWork W2115012087 @default.
• W2012029166 hasRelatedWork W2152192270 @default.
• W2012029166 hasRelatedWork W2156218985 @default.
• W2012029166 hasRelatedWork W2385076233 @default.
• W2012029166 hasRelatedWork W2778924093 @default.

• next