FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012029985> ?p ?o ?g. }

• W2012029985 endingPage "1302" @default.
• W2012029985 startingPage "1297" @default.
• W2012029985 abstract "Autoimmune hepatitis (AIH) is a chronic disease of unknown etiology, which usually progresses to cirrhosis if not diagnosed and treated promptly. Data on long-term follow up in children with AIH are scant. The aim of this study is to assess the long-term outcome of autoimmune hepatitis in children with respect to clinical and laboratory features at presentation.Data were extracted from the medical records of patients presenting over a 28-year period (1972-2000) to the Royal Children's Hospital, Melbourne, Australia. Additional information was obtained by interviewing patients, and their current physicians. Of the 30 patients (22 females, mean age 9 years) identified, 18 had type I, three had type II, four had autoimmune-polyendocrinopathy syndrome type 1, one had infantile giant-cell hepatitis associated with Coomb's-positive hemolytic anemia, and four were seronegative (antinuclear antibody (ANA), smooth muscle antibody (SMA) and liver-kidney microsomal antibody (LKM)).Clinical features at presentation included hepatomegaly (86%), jaundice (66%) and splenomegaly (50%). Initial investigations revealed a median serum bilirubin level of 55 micromol/L (range 6-425), median aspartate aminotransferase level of 678 IU (range 70-2548), and abnormal clotting in 33% of patients. Liver biopsies were performed on all patients at presentation and 11 showed cirrhosis (36%). The mean follow-up period was 10.0 +/- 7.8 years with 43% being followed for > 10 years. Only two patients died and one required transplantation. Fourteen (50%) patients continue to be on low dose prednisolone with azathioprine, two (7%) are on prednisolone alone, and six (21%) are on no therapy. When the cirrhotic and non-cirrhotic patients were compared, the albumin level at presentation was significantly lower in the cirrhotic group (P=0.01). Of the patients who were cirrhotic at presentation, six (54%) remain compensated with a mean follow-up period of 8 years. All 24 patients currently under follow up are engaged in age-appropriate activities including school, part- or full-time work.Autoimmune hepatitis has a favorable long-term outcome with a transplant-free survival rate of 90% over a mean period of 10.0 +/- 7.8 years (range: 0.5-23), and a normal or near-normal lifestyle irrespective of presenting clinical, laboratory or histological features." @default.
• W2012029985 created "2016-06-24" @default.
• W2012029985 creator A5011648249 @default.
• W2012029985 creator A5037877031 @default.
• W2012029985 creator A5061999503 @default.
• W2012029985 date "2001-11-01" @default.
• W2012029985 modified "2023-09-25" @default.
• W2012029985 title "Long-term outcome of autoimmune hepatitis in children" @default.
• W2012029985 cites W1727809390 @default.
• W2012029985 cites W1965809928 @default.
• W2012029985 cites W1995616322 @default.
• W2012029985 cites W2011976259 @default.
• W2012029985 cites W2038952814 @default.
• W2012029985 cites W2039049566 @default.
• W2012029985 cites W2049334361 @default.
• W2012029985 cites W2049968257 @default.
• W2012029985 cites W2063676055 @default.
• W2012029985 cites W2071556185 @default.
• W2012029985 cites W2071866793 @default.
• W2012029985 cites W2078135043 @default.
• W2012029985 cites W2089844380 @default.
• W2012029985 cites W2091218470 @default.
• W2012029985 cites W2099572876 @default.
• W2012029985 cites W2160126419 @default.
• W2012029985 cites W2170705556 @default.
• W2012029985 cites W2328996992 @default.
• W2012029985 cites W2331919277 @default.
• W2012029985 cites W4237426546 @default.
• W2012029985 cites W4297752219 @default.
• W2012029985 doi "https://doi.org/10.1046/j.1440-1746.2001.02615.x" @default.
• W2012029985 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11903750" @default.
• W2012029985 hasPublicationYear "2001" @default.
• W2012029985 type Work @default.
• W2012029985 sameAs 2012029985 @default.
• W2012029985 citedByCount "58" @default.
• W2012029985 countsByYear W20120299852012 @default.
• W2012029985 countsByYear W20120299852013 @default.
• W2012029985 countsByYear W20120299852014 @default.
• W2012029985 countsByYear W20120299852015 @default.
• W2012029985 countsByYear W20120299852017 @default.
• W2012029985 countsByYear W20120299852018 @default.
• W2012029985 countsByYear W20120299852019 @default.
• W2012029985 countsByYear W20120299852020 @default.
• W2012029985 countsByYear W20120299852021 @default.
• W2012029985 countsByYear W20120299852023 @default.
• W2012029985 crossrefType "journal-article" @default.
• W2012029985 hasAuthorship W2012029985A5011648249 @default.
• W2012029985 hasAuthorship W2012029985A5037877031 @default.
• W2012029985 hasAuthorship W2012029985A5061999503 @default.
• W2012029985 hasConcept C126322002 @default.
• W2012029985 hasConcept C149443304 @default.
• W2012029985 hasConcept C159654299 @default.
• W2012029985 hasConcept C163764329 @default.
• W2012029985 hasConcept C187212893 @default.
• W2012029985 hasConcept C203014093 @default.
• W2012029985 hasConcept C2776029263 @default.
• W2012029985 hasConcept C2776715498 @default.
• W2012029985 hasConcept C2776760755 @default.
• W2012029985 hasConcept C2777203481 @default.
• W2012029985 hasConcept C2777214474 @default.
• W2012029985 hasConcept C2777385706 @default.
• W2012029985 hasConcept C2778248108 @default.
• W2012029985 hasConcept C2778456037 @default.
• W2012029985 hasConcept C2779134260 @default.
• W2012029985 hasConcept C2779609443 @default.
• W2012029985 hasConcept C2911091166 @default.
• W2012029985 hasConcept C71924100 @default.
• W2012029985 hasConcept C90924648 @default.
• W2012029985 hasConceptScore W2012029985C126322002 @default.
• W2012029985 hasConceptScore W2012029985C149443304 @default.
• W2012029985 hasConceptScore W2012029985C159654299 @default.
• W2012029985 hasConceptScore W2012029985C163764329 @default.
• W2012029985 hasConceptScore W2012029985C187212893 @default.
• W2012029985 hasConceptScore W2012029985C203014093 @default.
• W2012029985 hasConceptScore W2012029985C2776029263 @default.
• W2012029985 hasConceptScore W2012029985C2776715498 @default.
• W2012029985 hasConceptScore W2012029985C2776760755 @default.
• W2012029985 hasConceptScore W2012029985C2777203481 @default.
• W2012029985 hasConceptScore W2012029985C2777214474 @default.
• W2012029985 hasConceptScore W2012029985C2777385706 @default.
• W2012029985 hasConceptScore W2012029985C2778248108 @default.
• W2012029985 hasConceptScore W2012029985C2778456037 @default.
• W2012029985 hasConceptScore W2012029985C2779134260 @default.
• W2012029985 hasConceptScore W2012029985C2779609443 @default.
• W2012029985 hasConceptScore W2012029985C2911091166 @default.
• W2012029985 hasConceptScore W2012029985C71924100 @default.
• W2012029985 hasConceptScore W2012029985C90924648 @default.
• W2012029985 hasIssue "11" @default.
• W2012029985 hasLocation W20120299851 @default.
• W2012029985 hasLocation W20120299852 @default.
• W2012029985 hasOpenAccess W2012029985 @default.
• W2012029985 hasPrimaryLocation W20120299851 @default.
• W2012029985 hasRelatedWork W2012029985 @default.
• W2012029985 hasRelatedWork W2049626078 @default.
• W2012029985 hasRelatedWork W2080958583 @default.
• W2012029985 hasRelatedWork W2092490460 @default.
• W2012029985 hasRelatedWork W2163145443 @default.
• W2012029985 hasRelatedWork W2299285988 @default.

• next