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- W2012030441 abstract "We have previously demonstrated that in vivo expression of the polyomavirus DNA-binding T-antigen initiated production of IgG antibodies to T-antigen and to DNA, but not to a panel of autoantigens not related to nucleosomes, indicating an antigen-selective T cell-dependent B cell response. In this study, we demonstrate that CD4-positive T cells from both normal and systemic lupus erythematosus (SLE) patients readily proliferate in response to pure T-antigen, and also to T-antigen in complex with nucleosomes. T-antigen-specific T cell lines from both normal individuals and SLE patients proliferate in response to nucleosome-T-antigen complexes, but not to nucleosomes or histones. B cells co-cultured with T-antigen-specific T cells and stimulated with nucleosome-T-antigen complexes produce anti-T-antigen and anti-DNA antibodies, indicating that such CD4-positive T cells have the potential to interact with B cells specific for individual components of nucleosome-T-antigen complexes. Thus, a non-self DNA-binding protein like polyomavirus T-antigen may initiate and maintain an antibody response to DNA when T-antigen is actively expressed." @default.
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- W2012030441 date "1999-09-01" @default.
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- W2012030441 title "T cell lines specific for polyomavirus T‐antigen recognize T‐antigen complexed with nucleosomes: a molecular basis for anti‐DNA antibody production" @default.
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- W2012030441 doi "https://doi.org/10.1002/(sici)1521-4141(199909)29:09<2715::aid-immu2715>3.0.co;2-#" @default.
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