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• W2012034657 abstract "We have shown that Hsp20, one of small molecular weight heat shock protein, which is present at a high concentration both in vascular smooth muscle cells and in circulating blood in patient with vascular disease, strongly inhibits platelet aggregation in vitro and ex vivo. To clarify the mechanism, we investigated the effect of Hsp20 on free calcium concentration in human platelet cytoplasm using fura 2. Hsp20 inhibited thrombin-induced calcium influx without affecting calcium release from intracellular calcium stores. The degree of inhibition is well-correlated with that of suppression of thrombin-induced platelet aggregation by this substance. Hsp20 also inhibited the elevation of cytoplasmic free calcium level triggered by collagen, but not that by A-23187. In contrast, Hsp28, another type of small molecular weight Hsp, failed to affect the cytoplasmic free calcium level. These findings suggest that Hsp20 inhibits the receptor-mediated calcium influx of platelets without affecting calcium release from intracellular calcium stores, leading to its anti-platelet activity." @default.
• W2012034657 created "2016-06-24" @default.
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• W2012034657 date "1999-11-01" @default.
• W2012034657 modified "2023-10-13" @default.
• W2012034657 title "Small molecular weight heat shock-related protein, HSP20, exhibits an anti-plate activity by inhibiting receptor-mediated calcium influx" @default.
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• W2012034657 doi "https://doi.org/10.1016/s0024-3205(99)00566-4" @default.
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