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• W2012037204 abstract "SUMMARY The potential of central nervous system (CNS)-derived cells for initiating T cell responses is not known. Using the capacity of unprimed T cells to respond to allogeneic determinants on antigen presenting cells (APC). we assessed the ability of microglial cells lo act as stimulators of primary T cell responses in vitro. For this purpose, microglial cells were activated with lipopolysaccharide (LPS). interferon-gamma (IFN-γ), or by phagocytosis of progenitor oligodendrocytes and subsequently tested for their ability to induce a proliferative response of naive, resting T cells. Activated microglial cells induced a significant proliferation of virgin, alloreactive CD4+ and CD8+ T lymphocytes, with a more substantial response of highly purified CD4+ than of CD8+ expressing T cells. Phagocytosis activation was the most efficient stimulus to induce this APC competence on microglial cells. By contrast. IFN-γ pretreated. MHC-expressing astrocytes were unable to induce similar responses of alloreactive CD4+ or CD8+ T cells under the same experimental conditions. Collectively, our data suggest the role of activated microglia as the fully immunocompetent accessory cell population of the CNS." @default.
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• W2012037204 date "1994-11-01" @default.
• W2012037204 modified "2023-09-25" @default.
• W2012037204 title "Microglial cells qualify as the stimulators of unprimed CD4+ and CD8+ T lymphocytes in the central nervous system" @default.
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• W2012037204 doi "https://doi.org/10.1111/j.1365-2249.1994.tb06143.x" @default.
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