FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012037973> ?p ?o ?g. }

• W2012037973 endingPage "727" @default.
• W2012037973 startingPage "717" @default.
• W2012037973 abstract "Abstract The thermo-stability and unfolding behaviors of a small hyperthermophilic protein Sso7d as well as its single-point mutation F31A are studied by molecular dynamics simulation at temperatures of 300 K, 371 K and 500 K. Simulations at 300 K show that the F31A mutant displays a much larger flexibility than the wild type, which implies that the mutation obviously decreases the protein's stability. In the simulations at 371 K, although larger fluctuations were observed, both of these two maintain their stable conformations. High temperature simulations at 500 K suggest that the unfolding of these two proteins evolves along different pathways. For the wild-type protein, the C-terminal alpha-helix is melted at the early unfolding stage, whereas it is destroyed much later in the unfolding process of the F31A mutant. The results also show that the mutant unfolds much faster than its parent protein. The deeply buried aromatic cluster in the F31A mutant dissociates quickly relative to the wild-type protein at high temperature. Besides, it is found that the triple-stranded antiparallel β-sheet in the wild-type protein plays an important role in maintaining the stability of the entire structure." @default.
• W2012037973 created "2016-06-24" @default.
• W2012037973 creator A5013264665 @default.
• W2012037973 creator A5022829684 @default.
• W2012037973 creator A5031008495 @default.
• W2012037973 creator A5032107354 @default.
• W2012037973 date "2011-04-01" @default.
• W2012037973 modified "2023-09-25" @default.
• W2012037973 title "Thermal Stability and Unfolding Pathways of Sso7d and its Mutant F31A: Insight from Molecular Dynamics Simulation" @default.
• W2012037973 cites W1491824558 @default.
• W2012037973 cites W1965831294 @default.
• W2012037973 cites W1966078827 @default.
• W2012037973 cites W1970188297 @default.
• W2012037973 cites W1972018992 @default.
• W2012037973 cites W1974571830 @default.
• W2012037973 cites W1977428203 @default.
• W2012037973 cites W1978774930 @default.
• W2012037973 cites W1982140052 @default.
• W2012037973 cites W1983131627 @default.
• W2012037973 cites W1987018075 @default.
• W2012037973 cites W1989960825 @default.
• W2012037973 cites W1989967805 @default.
• W2012037973 cites W1994659915 @default.
• W2012037973 cites W1997538073 @default.
• W2012037973 cites W1998540108 @default.
• W2012037973 cites W2008708467 @default.
• W2012037973 cites W2011015069 @default.
• W2012037973 cites W2012814922 @default.
• W2012037973 cites W2013673509 @default.
• W2012037973 cites W2018472751 @default.
• W2012037973 cites W2023538673 @default.
• W2012037973 cites W2028501277 @default.
• W2012037973 cites W2029667189 @default.
• W2012037973 cites W2031537429 @default.
• W2012037973 cites W2035687084 @default.
• W2012037973 cites W2036120077 @default.
• W2012037973 cites W2037199311 @default.
• W2012037973 cites W2038530943 @default.
• W2012037973 cites W2038816113 @default.
• W2012037973 cites W2039146785 @default.
• W2012037973 cites W2039168333 @default.
• W2012037973 cites W2041447979 @default.
• W2012037973 cites W2043174540 @default.
• W2012037973 cites W2044035813 @default.
• W2012037973 cites W2051664585 @default.
• W2012037973 cites W2052132071 @default.
• W2012037973 cites W2053834405 @default.
• W2012037973 cites W2053872025 @default.
• W2012037973 cites W2056103246 @default.
• W2012037973 cites W2057477511 @default.
• W2012037973 cites W2058273720 @default.
• W2012037973 cites W2059515614 @default.
• W2012037973 cites W2060089658 @default.
• W2012037973 cites W2064184077 @default.
• W2012037973 cites W2068340168 @default.
• W2012037973 cites W2072542651 @default.
• W2012037973 cites W2075981452 @default.
• W2012037973 cites W2081693079 @default.
• W2012037973 cites W2083947944 @default.
• W2012037973 cites W2084607551 @default.
• W2012037973 cites W2085961415 @default.
• W2012037973 cites W2087188635 @default.
• W2012037973 cites W2094186244 @default.
• W2012037973 cites W2112398397 @default.
• W2012037973 cites W2113729114 @default.
• W2012037973 cites W2128572087 @default.
• W2012037973 cites W2130343759 @default.
• W2012037973 cites W2143173111 @default.
• W2012037973 cites W2156084923 @default.
• W2012037973 cites W2158543301 @default.
• W2012037973 cites W2163540229 @default.
• W2012037973 cites W2166113452 @default.
• W2012037973 cites W2166552772 @default.
• W2012037973 cites W2171268876 @default.
• W2012037973 cites W2172194876 @default.
• W2012037973 cites W4252930922 @default.
• W2012037973 doi "https://doi.org/10.1080/07391102.2011.10508601" @default.
• W2012037973 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21294584" @default.
• W2012037973 hasPublicationYear "2011" @default.
• W2012037973 type Work @default.
• W2012037973 sameAs 2012037973 @default.
• W2012037973 citedByCount "21" @default.
• W2012037973 countsByYear W20120379732012 @default.
• W2012037973 countsByYear W20120379732013 @default.
• W2012037973 countsByYear W20120379732014 @default.
• W2012037973 countsByYear W20120379732015 @default.
• W2012037973 countsByYear W20120379732016 @default.
• W2012037973 countsByYear W20120379732017 @default.
• W2012037973 countsByYear W20120379732020 @default.
• W2012037973 crossrefType "journal-article" @default.
• W2012037973 hasAuthorship W2012037973A5013264665 @default.
• W2012037973 hasAuthorship W2012037973A5022829684 @default.
• W2012037973 hasAuthorship W2012037973A5031008495 @default.
• W2012037973 hasAuthorship W2012037973A5032107354 @default.
• W2012037973 hasConcept C104317684 @default.
• W2012037973 hasConcept C115260700 @default.
• W2012037973 hasConcept C121332964 @default.
• W2012037973 hasConcept C12554922 @default.

• next