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• W2012040248 abstract "A variety of environmentally persistent contaminants of the Great Lakes Basin are able to bioaccumulate in the aquatic food chain and pose a threat to the health and reproductive success of people and wildlife that depend on locally caught fish as a source of dietary protein. Exposure to polychlorinated biphenyls (PCBs) and 1,1-bis(4-chlorophenyl)-2,2-dichloroethene (DDE) has been linked to higher rates of cancer, reproductive problems, and endocrine disorders. To investigate the effects of exposure to persistent contaminants of the Great Lakes Basin, the health departments of five Great Lakes states formed a health-assessment consortium. Between 1988 and 1994, the consortium collected demographic and fish consumption information from 2548 licensed charter boat captains, 182 anglers, and 1667 referents. Between 1994 and 1995, a subset of 619 participants in this study provided additional fish consumption information and donated blood samples that were analyzed for PCBs and DDE. Follow-up studies conducted between 2001 and 2005 re-assessed fish consumption rates and blood levels of PCBs and DDE in 293 of these individuals. While there was a trend for increasing overall fish consumption among most participant groups, sportfish and Great Lakes sportfish consumption decreased significantly in the captains over the study period. Serum DDE concentrations, which were highest in men in the captain and angler groups, declined in 90% of study participants. Mean DDE levels fell from 5.6 to 3.2 microg/L. Total PCB levels declined in 80% of participants with the mean concentration falling from 4.2 to 2.8 microg/L. Annual declines in serum DDE and PCB concentrations averaged 4.6% and 3.5%, respectively." @default.
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• W2012040248 date "2009-01-01" @default.
• W2012040248 modified "2023-10-06" @default.
• W2012040248 title "Temporal changes in PCB and DDE levels among a cohort of frequent and infrequent consumers of Great Lakes sportfish" @default.
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• W2012040248 doi "https://doi.org/10.1016/j.envres.2008.08.010" @default.
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