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• W2012040700 abstract "ABSTRACT The cupA gene cluster of Pseudomonas aeruginosa encodes components and assembly factors of a putative fimbrial structure that enable this opportunistic pathogen to form biofilms on abiotic surfaces. In P. aeruginosa the control of cupA gene expression is complex, with the H-NS-like MvaT protein functioning to repress phase-variable (on/off) expression of the operon. Here we identify four positive regulators of cupA gene expression, including three unusual regulators encoded by the cgrABC genes and Anr, a global regulator of anaerobic gene expression. We show that the cupA genes are expressed in a phase-variable manner under anaerobic conditions and that the cgr genes are essential for this expression. We show further that cgr gene expression is negatively controlled by MvaT and positively controlled by Anr and anaerobiosis. Expression of the cupA genes therefore appears to involve a regulatory cascade in which anaerobiosis, signaled through Anr, stimulates expression of the cgr genes, resulting in a concomitant increase in cupA gene expression. Our findings thus provide mechanistic insight into the regulation of cupA gene expression and identify anaerobiosis as an inducer of phase-variable cupA gene expression, raising the possibility that phase-variable expression of fimbrial genes important for biofilm formation may occur in P. aeruginosa persisting in the largely anaerobic environment of the cystic fibrosis host lung." @default.
• W2012040700 created "2016-06-24" @default.
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• W2012040700 date "2007-12-01" @default.
• W2012040700 modified "2023-10-18" @default.
• W2012040700 title "Local and Global Regulators Linking Anaerobiosis to <i>cupA</i> Fimbrial Gene Expression in <i>Pseudomonas aeruginosa</i>" @default.
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• W2012040700 doi "https://doi.org/10.1128/jb.01344-07" @default.
• W2012040700 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2168922" @default.
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