FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012043013> ?p ?o ?g. }

• W2012043013 endingPage "602" @default.
• W2012043013 startingPage "597" @default.
• W2012043013 abstract "Introduction Selective internal radiation therapy (SIRT) is emerging as a new therapeutic modality in recent years for management of non-resectable hepatic malignancies. Our experience in clinical application of this treatment is reported here. Material and methods From June 2004, patients whose liver tumours were no longer amenable for any conventional treatment with either chemotherapy or surgery were considered for yttrium-90 microspheres treatment after discussion at our multidisciplinary meeting. A pre-treatment planning was carried out with visceral angiography and technetium-99m macroaggregated albumin (MAA) for assessment of both tumour volume and extrahepatic shunting in addition to a baseline PET and CT scans, respectively. Two weeks later, a second visceral angiogram was performed to deliver the calculated dosage of microspheres into the arterial system supplying the tumour. Patients were then followed up with tumour markers, repeat PET and CT scans of abdomen at 6 weeks and 3 monthly thereafter. Result Twenty-one patients (F=11, M=10; age range 40–75 years, mean=58 years) received yttrium-90 microspheres consisting of liver metastases from colorectal primary (n=10) and non-colorectal primaries (n=8), and primary liver tumours (n=3). One patient received 2 treatments. The mean administered activity of microspheres delivered was 1.9 GBq (range 1.2–2.5 GBq). Injection of microspheres had no immediate effect on either clinical haematology or liver function tests. At follow-up, 86% of patients showed decreased activity on PET scan at 6 weeks (p=0.01). The mean pre-treatment SUV was 12.2±3.7 and the mean post-treatment SUV was 9.3±3.7, indicating a significant improvement measured with PET activity. Only 13% showed a reduction in the size of tumour on CT scan. For patients with colorectal liver metastases, there was no significant reduction in CEA level (127±115 vs 75±72 μ/l, p=0.39). Complications were seen in 4 patients (19%) including radiation hepatitis (n=2), cholecystitis (n=1) and duodenal ulceration (n=1). All resolved without surgical intervention. Seven patients died at follow-up from progressive extrahepatic disease (33%). Conclusion SIRT should be considered for patients with advanced liver cancer. It has a significant effect on liver disease in the absence of extrahepatic disease. PET imaging has an integral role in the assessment of patients treated with yttrium-90 SIR-Spheres." @default.
• W2012043013 created "2016-06-24" @default.
• W2012043013 creator A5000411947 @default.
• W2012043013 creator A5022505331 @default.
• W2012043013 creator A5027956350 @default.
• W2012043013 creator A5034758837 @default.
• W2012043013 creator A5036143326 @default.
• W2012043013 creator A5037998112 @default.
• W2012043013 creator A5042869404 @default.
• W2012043013 creator A5047800429 @default.
• W2012043013 creator A5048260709 @default.
• W2012043013 creator A5053323102 @default.
• W2012043013 creator A5059462029 @default.
• W2012043013 creator A5063738443 @default.
• W2012043013 creator A5069234120 @default.
• W2012043013 creator A5073435349 @default.
• W2012043013 creator A5075021785 @default.
• W2012043013 date "2007-06-01" @default.
• W2012043013 modified "2023-09-27" @default.
• W2012043013 title "Clinical and imaging experience with yttrium-90 microspheres in the management of unresectable liver tumours" @default.
• W2012043013 cites W1570173114 @default.
• W2012043013 cites W1968090673 @default.
• W2012043013 cites W1974613296 @default.
• W2012043013 cites W1982458466 @default.
• W2012043013 cites W1985670289 @default.
• W2012043013 cites W1995006782 @default.
• W2012043013 cites W2035779983 @default.
• W2012043013 cites W2037435427 @default.
• W2012043013 cites W2058981324 @default.
• W2012043013 cites W2082466657 @default.
• W2012043013 cites W2088591216 @default.
• W2012043013 cites W2089242758 @default.
• W2012043013 cites W2094306687 @default.
• W2012043013 cites W2131740088 @default.
• W2012043013 cites W2139248078 @default.
• W2012043013 cites W2156946556 @default.
• W2012043013 cites W2169874604 @default.
• W2012043013 doi "https://doi.org/10.1016/j.ejso.2007.02.021" @default.
• W2012043013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17433608" @default.
• W2012043013 hasPublicationYear "2007" @default.
• W2012043013 type Work @default.
• W2012043013 sameAs 2012043013 @default.
• W2012043013 citedByCount "42" @default.
• W2012043013 countsByYear W20120430132012 @default.
• W2012043013 countsByYear W20120430132013 @default.
• W2012043013 countsByYear W20120430132014 @default.
• W2012043013 countsByYear W20120430132015 @default.
• W2012043013 countsByYear W20120430132017 @default.
• W2012043013 countsByYear W20120430132019 @default.
• W2012043013 crossrefType "journal-article" @default.
• W2012043013 hasAuthorship W2012043013A5000411947 @default.
• W2012043013 hasAuthorship W2012043013A5022505331 @default.
• W2012043013 hasAuthorship W2012043013A5027956350 @default.
• W2012043013 hasAuthorship W2012043013A5034758837 @default.
• W2012043013 hasAuthorship W2012043013A5036143326 @default.
• W2012043013 hasAuthorship W2012043013A5037998112 @default.
• W2012043013 hasAuthorship W2012043013A5042869404 @default.
• W2012043013 hasAuthorship W2012043013A5047800429 @default.
• W2012043013 hasAuthorship W2012043013A5048260709 @default.
• W2012043013 hasAuthorship W2012043013A5053323102 @default.
• W2012043013 hasAuthorship W2012043013A5059462029 @default.
• W2012043013 hasAuthorship W2012043013A5063738443 @default.
• W2012043013 hasAuthorship W2012043013A5069234120 @default.
• W2012043013 hasAuthorship W2012043013A5073435349 @default.
• W2012043013 hasAuthorship W2012043013A5075021785 @default.
• W2012043013 hasConcept C126322002 @default.
• W2012043013 hasConcept C126838900 @default.
• W2012043013 hasConcept C127413603 @default.
• W2012043013 hasConcept C189942447 @default.
• W2012043013 hasConcept C2776694085 @default.
• W2012043013 hasConcept C2778019345 @default.
• W2012043013 hasConcept C2779185275 @default.
• W2012043013 hasConcept C2779983558 @default.
• W2012043013 hasConcept C2780643987 @default.
• W2012043013 hasConcept C2989005 @default.
• W2012043013 hasConcept C42360764 @default.
• W2012043013 hasConcept C509974204 @default.
• W2012043013 hasConcept C71924100 @default.
• W2012043013 hasConceptScore W2012043013C126322002 @default.
• W2012043013 hasConceptScore W2012043013C126838900 @default.
• W2012043013 hasConceptScore W2012043013C127413603 @default.
• W2012043013 hasConceptScore W2012043013C189942447 @default.
• W2012043013 hasConceptScore W2012043013C2776694085 @default.
• W2012043013 hasConceptScore W2012043013C2778019345 @default.
• W2012043013 hasConceptScore W2012043013C2779185275 @default.
• W2012043013 hasConceptScore W2012043013C2779983558 @default.
• W2012043013 hasConceptScore W2012043013C2780643987 @default.
• W2012043013 hasConceptScore W2012043013C2989005 @default.
• W2012043013 hasConceptScore W2012043013C42360764 @default.
• W2012043013 hasConceptScore W2012043013C509974204 @default.
• W2012043013 hasConceptScore W2012043013C71924100 @default.
• W2012043013 hasIssue "5" @default.
• W2012043013 hasLocation W20120430131 @default.
• W2012043013 hasLocation W20120430132 @default.
• W2012043013 hasOpenAccess W2012043013 @default.
• W2012043013 hasPrimaryLocation W20120430131 @default.
• W2012043013 hasRelatedWork W1992463603 @default.
• W2012043013 hasRelatedWork W2067116879 @default.

• next