FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012044315> ?p ?o ?g. }

• W2012044315 endingPage "144" @default.
• W2012044315 startingPage "133" @default.
• W2012044315 abstract "Cells rely heavily on cues from their extracellular environment and other cells to coordinate normal physiological processes, and the exchange of molecules via gap junctions has been suggested as an important avenue for cell-cell communication. Gap junctions are found in virtually all mammalian tissues with the notable exception of adult skeletal muscle. However, since functional gap junctions have been detected during the early stages of muscle development, gap junctional intercellular communication (GJIC) may play an important role in myogenesis. In this study, GJIC in normal L6 myoblasts was inhibited using the known blockers 1-octanal and β-glycyrrhetinic acid (β-GA). Under differentiation promoting conditions, L6 cells fused to form multinucleated myotubes, but when treated with either octanol or β-GA, no fusion was observed. The expression of two muscle regulatory factors (MRFs), myogenin and MRF4, was examined in both the blocked and control cells. As expected, the activation of both the myogenin and MRF4 genes coincided with the onset of differentiation in the control L6 cells. Neither of these genes were turned on in the blocked cells, even when grown under low serum conditions. This inhibition of differentiation by octanol and β-GA was reversible, since the activation of both MRF genes as well as myoblast fusion were observed when the blocking medium was replaced with normal differentiating medium. These results suggest that intercellular communication via gap junctions plays an important role in skeletal muscle development and perhaps in the cell signaling events that trigger the activation of muscle-specific MRF genes. Dev. Genet. 20:133–144. 1997. © 1997 Wiley-Liss, Inc." @default.
• W2012044315 created "2016-06-24" @default.
• W2012044315 creator A5009578649 @default.
• W2012044315 creator A5060119478 @default.
• W2012044315 creator A5067397254 @default.
• W2012044315 date "1997-01-01" @default.
• W2012044315 modified "2023-09-29" @default.
• W2012044315 title "Blocking gap junctional intercellular communication in myoblasts inhibits myogenin and MRF4 expression" @default.
• W2012044315 cites W1519779876 @default.
• W2012044315 cites W162490457 @default.
• W2012044315 cites W1791228580 @default.
• W2012044315 cites W1826748661 @default.
• W2012044315 cites W1888061403 @default.
• W2012044315 cites W1956478448 @default.
• W2012044315 cites W1964613075 @default.
• W2012044315 cites W1964733862 @default.
• W2012044315 cites W1966387132 @default.
• W2012044315 cites W1970644481 @default.
• W2012044315 cites W1983214878 @default.
• W2012044315 cites W1998447946 @default.
• W2012044315 cites W1998619406 @default.
• W2012044315 cites W2003794786 @default.
• W2012044315 cites W2012826978 @default.
• W2012044315 cites W2014716519 @default.
• W2012044315 cites W2032171471 @default.
• W2012044315 cites W2038154593 @default.
• W2012044315 cites W2040168630 @default.
• W2012044315 cites W2040526045 @default.
• W2012044315 cites W2041401980 @default.
• W2012044315 cites W2041652972 @default.
• W2012044315 cites W2054954176 @default.
• W2012044315 cites W2056464472 @default.
• W2012044315 cites W2056826467 @default.
• W2012044315 cites W2063489051 @default.
• W2012044315 cites W2069094132 @default.
• W2012044315 cites W2076282408 @default.
• W2012044315 cites W2076875187 @default.
• W2012044315 cites W2078718449 @default.
• W2012044315 cites W2083134916 @default.
• W2012044315 cites W2086080160 @default.
• W2012044315 cites W2089800175 @default.
• W2012044315 cites W2090627913 @default.
• W2012044315 cites W2094188824 @default.
• W2012044315 cites W2094362923 @default.
• W2012044315 cites W2101129619 @default.
• W2012044315 cites W2103735500 @default.
• W2012044315 cites W2122699622 @default.
• W2012044315 cites W2123499039 @default.
• W2012044315 cites W2123929920 @default.
• W2012044315 cites W2128940002 @default.
• W2012044315 cites W2156103307 @default.
• W2012044315 cites W2160438364 @default.
• W2012044315 cites W2177035195 @default.
• W2012044315 cites W2256783719 @default.
• W2012044315 cites W4255670149 @default.
• W2012044315 cites W51927943 @default.
• W2012044315 doi "https://doi.org/10.1002/(sici)1520-6408(1997)20:2<133::aid-dvg6>3.0.co;2-8" @default.
• W2012044315 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9144924" @default.
• W2012044315 hasPublicationYear "1997" @default.
• W2012044315 type Work @default.
• W2012044315 sameAs 2012044315 @default.
• W2012044315 citedByCount "67" @default.
• W2012044315 countsByYear W20120443152012 @default.
• W2012044315 countsByYear W20120443152013 @default.
• W2012044315 countsByYear W20120443152014 @default.
• W2012044315 countsByYear W20120443152015 @default.
• W2012044315 countsByYear W20120443152016 @default.
• W2012044315 countsByYear W20120443152017 @default.
• W2012044315 countsByYear W20120443152019 @default.
• W2012044315 countsByYear W20120443152020 @default.
• W2012044315 countsByYear W20120443152021 @default.
• W2012044315 countsByYear W20120443152022 @default.
• W2012044315 crossrefType "journal-article" @default.
• W2012044315 hasAuthorship W2012044315A5009578649 @default.
• W2012044315 hasAuthorship W2012044315A5060119478 @default.
• W2012044315 hasAuthorship W2012044315A5067397254 @default.
• W2012044315 hasConcept C105702510 @default.
• W2012044315 hasConcept C1491633281 @default.
• W2012044315 hasConcept C158157758 @default.
• W2012044315 hasConcept C207200792 @default.
• W2012044315 hasConcept C2779959927 @default.
• W2012044315 hasConcept C28406088 @default.
• W2012044315 hasConcept C3763915 @default.
• W2012044315 hasConcept C55493867 @default.
• W2012044315 hasConcept C79879829 @default.
• W2012044315 hasConcept C86803240 @default.
• W2012044315 hasConcept C92488253 @default.
• W2012044315 hasConcept C95444343 @default.
• W2012044315 hasConcept C97816823 @default.
• W2012044315 hasConceptScore W2012044315C105702510 @default.
• W2012044315 hasConceptScore W2012044315C1491633281 @default.
• W2012044315 hasConceptScore W2012044315C158157758 @default.
• W2012044315 hasConceptScore W2012044315C207200792 @default.
• W2012044315 hasConceptScore W2012044315C2779959927 @default.
• W2012044315 hasConceptScore W2012044315C28406088 @default.
• W2012044315 hasConceptScore W2012044315C3763915 @default.
• W2012044315 hasConceptScore W2012044315C55493867 @default.
• W2012044315 hasConceptScore W2012044315C79879829 @default.

• next