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• W2012044764 startingPage "98" @default.
• W2012044764 abstract "Superparamagnetic iron oxide nanoparticles (SPM particles) are used in MRI to highlight regions such as tumors through negative contrast. Unfortunately, sources as air bubbles or tissues interfaces also lead to negative contrast, which complicates the image interpretation. New MRI sequences creating positive contrast in the particle surrounding, such as the Off-Resonance Saturation sequence (ORS), have thus been developed. However, a theoretical study of the ORS sequence is still lacking, which hampers the optimization of this sequence. For this reason, this work provides a self-consistent analytical expression able to predict the dependence of the contrast on the sequence parameters and the SPM particles properties. This expression was validated by numerical simulations and experiments on agarose gel phantoms on a 11.7 T scanner system. It provides a fundamental understanding of the mechanisms leading to positive contrast, which could allow the improvement of the sequence for future in vivo applications. The influence of the SPM particle relaxivities, the SPM particle concentration, the echo time and the saturation pulse parameters on the contrast were investigated. The best contrast was achieved with SPM particles possessing the smallest transverse relaxivity, an optimal particle concentration and for low echo times." @default.
• W2012044764 created "2016-06-24" @default.
• W2012044764 creator A5010279808 @default.
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• W2012044764 date "2015-05-01" @default.
• W2012044764 modified "2023-09-25" @default.
• W2012044764 title "Bottom-up study of the MRI positive contrast created by the Off-Resonance Saturation sequence" @default.
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• W2012044764 doi "https://doi.org/10.1016/j.jmr.2015.02.014" @default.
• W2012044764 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25863894" @default.
• W2012044764 hasPublicationYear "2015" @default.
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