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- W2012045168 abstract "G A A b st ra ct s (40-69), 2440 (62%) males, consented to participate in this study. Of these, 2166 patients who had 1stand 2nd-TCS, with removal of all adenomatous polyps were randomly assigned into two groups (1087 to two-exam and 1079 to one-exam group). The results of the noninferiority test were significant (p=0.017 in per-protocol, p=0.001 in intention-to-treat). In per-protocol analysis (701 in two-exam vs 763 in one-exam group), the IL incidences of two groups were similar (1.7% vs 2.1%). The percentage of patients with adenomas in twoexam was 50.1%, versus 37.7% in one-exam group. Among all ILs, there were 6 LGD ≥10mm, 5 HGD and 1 invasive cancer in two-exam, 9 LGD ≥10mm and 8 HGD in oneexam group, respectively. Morphologically, NP-CRNs were dominant (62%, 18/29) and most of them were classified into laterally spreading tumor non-granular (LST-NG) type; (83%, 15/18). Moreover, 7 out of 15 ILs classified into LST-NG were histologically diagnosed as HGD. Conclusions: Colonoscopy performed 3 years after endoscopic removal of all adenomatous polyps detected clinically important lesions as effectively as follow-up colonoscopy after both 1 and 3 years, being such results in accordance with those of the NPS. Two complete colonoscopies before randomization provided us a lower incidence of ILs compared with NPS data (3.3%). Further investigation will be necessary to evaluate whether the detection of NP-CRNs, especially LST-NG type determines a change in the prevention of colorectal cancer." @default.
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- W2012045168 date "2014-05-01" @default.
- W2012045168 modified "2023-09-27" @default.
- W2012045168 title "937 Barriers, Misconceptions and the Lack of Physicians' Recommendation Account for Poor Screening Uptake in Colorectal Compared With Cervical Cancer: Findings of a National Population Representative Survey" @default.
- W2012045168 doi "https://doi.org/10.1016/s0016-5085(14)60579-5" @default.
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