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- W2012046458 abstract "Here we report AWP28, an activity-based probe that can be used to biochemically monitor caspase-1 activation in response to proinflammatory stimuli. Using AWP28, we show that apoptosis is triggered upon Salmonella enterica var. Typhimurium infection in primary mouse bone marrow macrophages lacking caspase-1. Furthermore, we report that upon Salmonella infection, inflammasome-mediated caspase-1 activity is required to bypass apoptosis in favor of proinflammatory pyroptotic cell death." @default.
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- W2012046458 date "2012-07-15" @default.
- W2012046458 modified "2023-09-30" @default.
- W2012046458 title "Caspase-1 activity is required to bypass macrophage apoptosis upon Salmonella infection" @default.
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- W2012046458 doi "https://doi.org/10.1038/nchembio.1023" @default.
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