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• W2012047868 abstract "Epidermal keratinocytes are important sources of a wide variety of cytokines that include the Granulocyte-macrophage Colony Stimulating Factor (GM-CSF). Glucocorticoids have been shown to inhibit the production of several cytokines. However, their effect on GM-CSF synthesis by keratinocytes is still unknown.The effects of glucocorticoid on GM-CSF production by keratinocytes were evaluated using ELISA and RT-PCR analysis.GM-CSF secretion by HaCaT cells increased with increasing UVB exposure. Dexamethasone suppressed basal release of GM-CSE In addition, it strongly inhibited both the UVB-mediated augmentation of GM-CSF protein production and mRNA expression. Lincomycin enhanced slightly the inhibitory effect of dexamethasone on GM-CSF synthesis, while lincomycin itself had no effect on GM-CSF secretion.Results showed that dexamethasone suppressed basal release and UVB-induced production of GM-CSF by keratinocytes." @default.
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• W2012047868 date "2001-06-01" @default.
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• W2012047868 title "UVB-induced GM-CSF production is suppressed by dexamethasone in HaCaT Cells" @default.
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• W2012047868 doi "https://doi.org/10.1034/j.1600-0781.2001.170303.x" @default.
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