Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012050433> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2012050433 endingPage "311" @default.
- W2012050433 startingPage "304" @default.
- W2012050433 abstract "In vertebrates, melanin production is restricted to pigment cells. This cell type-specific melanogenesis is considered to involve cell type-specific expression of the tyrosinase gene. Recently, there have been several reports that sequences in the 5' flanking region of the mouse tyrosinase gene are responsible for cell type-specific expression of the transgene in mice. As the first step in the study of the evolution of the regulatory mechanisms for tyrosinase gene function in vertebrates, we constructed a fused gene, hg-Tyrs-J, which includes a 1.0-kb 5' flanking sequence of the human tyrosinase gene fused with mouse tyrosinase cDNA. By introducing the fused gene into fertilized eggs of albino mice, we obtained two mice that exhibited pigmentation in the skin and eyes and established a transgenic line from one of them. Further analyses revealed that the transgene was expressed cell type-specifically in these transgenic mice. We conclude, therefore, that the 1.0 kb 5' upstream region of the human tyrosinase gene contains conserved cis-elements essential for cell type-specific expression of the tyrosinase genes in mice and humans. Results of our study may provide a clue to elucidate the evolutionary process of regulatory mechanisms of the tyrosinase gene." @default.
- W2012050433 created "2016-06-24" @default.
- W2012050433 creator A5006650517 @default.
- W2012050433 creator A5007326448 @default.
- W2012050433 creator A5010143923 @default.
- W2012050433 creator A5036256585 @default.
- W2012050433 creator A5043597779 @default.
- W2012050433 creator A5059173679 @default.
- W2012050433 date "1992-11-01" @default.
- W2012050433 modified "2023-10-13" @default.
- W2012050433 title "Conserved Regulatory Mechanisms of Tyrosinase Genes in Mice and Humans" @default.
- W2012050433 cites W1485368845 @default.
- W2012050433 cites W1724938793 @default.
- W2012050433 cites W1846466764 @default.
- W2012050433 cites W1966411585 @default.
- W2012050433 cites W1990458909 @default.
- W2012050433 cites W2036927188 @default.
- W2012050433 cites W2037825606 @default.
- W2012050433 cites W2072606138 @default.
- W2012050433 cites W2087385837 @default.
- W2012050433 cites W2134812217 @default.
- W2012050433 cites W2139242491 @default.
- W2012050433 cites W2140392158 @default.
- W2012050433 cites W2160499114 @default.
- W2012050433 cites W2164620775 @default.
- W2012050433 cites W2492441292 @default.
- W2012050433 doi "https://doi.org/10.1111/j.1600-0749.1992.tb00554.x" @default.
- W2012050433 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1283999" @default.
- W2012050433 hasPublicationYear "1992" @default.
- W2012050433 type Work @default.
- W2012050433 sameAs 2012050433 @default.
- W2012050433 citedByCount "10" @default.
- W2012050433 crossrefType "journal-article" @default.
- W2012050433 hasAuthorship W2012050433A5006650517 @default.
- W2012050433 hasAuthorship W2012050433A5007326448 @default.
- W2012050433 hasAuthorship W2012050433A5010143923 @default.
- W2012050433 hasAuthorship W2012050433A5036256585 @default.
- W2012050433 hasAuthorship W2012050433A5043597779 @default.
- W2012050433 hasAuthorship W2012050433A5059173679 @default.
- W2012050433 hasConcept C102230213 @default.
- W2012050433 hasConcept C104317684 @default.
- W2012050433 hasConcept C107538193 @default.
- W2012050433 hasConcept C141035611 @default.
- W2012050433 hasConcept C1491633281 @default.
- W2012050433 hasConcept C150194340 @default.
- W2012050433 hasConcept C153911025 @default.
- W2012050433 hasConcept C181199279 @default.
- W2012050433 hasConcept C187882448 @default.
- W2012050433 hasConcept C189014844 @default.
- W2012050433 hasConcept C21592294 @default.
- W2012050433 hasConcept C54355233 @default.
- W2012050433 hasConcept C55493867 @default.
- W2012050433 hasConcept C86803240 @default.
- W2012050433 hasConcept C87554066 @default.
- W2012050433 hasConcept C95444343 @default.
- W2012050433 hasConceptScore W2012050433C102230213 @default.
- W2012050433 hasConceptScore W2012050433C104317684 @default.
- W2012050433 hasConceptScore W2012050433C107538193 @default.
- W2012050433 hasConceptScore W2012050433C141035611 @default.
- W2012050433 hasConceptScore W2012050433C1491633281 @default.
- W2012050433 hasConceptScore W2012050433C150194340 @default.
- W2012050433 hasConceptScore W2012050433C153911025 @default.
- W2012050433 hasConceptScore W2012050433C181199279 @default.
- W2012050433 hasConceptScore W2012050433C187882448 @default.
- W2012050433 hasConceptScore W2012050433C189014844 @default.
- W2012050433 hasConceptScore W2012050433C21592294 @default.
- W2012050433 hasConceptScore W2012050433C54355233 @default.
- W2012050433 hasConceptScore W2012050433C55493867 @default.
- W2012050433 hasConceptScore W2012050433C86803240 @default.
- W2012050433 hasConceptScore W2012050433C87554066 @default.
- W2012050433 hasConceptScore W2012050433C95444343 @default.
- W2012050433 hasIssue "5" @default.
- W2012050433 hasLocation W20120504331 @default.
- W2012050433 hasLocation W20120504332 @default.
- W2012050433 hasOpenAccess W2012050433 @default.
- W2012050433 hasPrimaryLocation W20120504331 @default.
- W2012050433 hasRelatedWork W1508960292 @default.
- W2012050433 hasRelatedWork W2030652313 @default.
- W2012050433 hasRelatedWork W2052929645 @default.
- W2012050433 hasRelatedWork W2272150713 @default.
- W2012050433 hasRelatedWork W2355986471 @default.
- W2012050433 hasRelatedWork W3036944250 @default.
- W2012050433 hasRelatedWork W3111381153 @default.
- W2012050433 hasRelatedWork W35925915 @default.
- W2012050433 hasRelatedWork W4290160112 @default.
- W2012050433 hasRelatedWork W2470596946 @default.
- W2012050433 hasVolume "5" @default.
- W2012050433 isParatext "false" @default.
- W2012050433 isRetracted "false" @default.
- W2012050433 magId "2012050433" @default.
- W2012050433 workType "article" @default.