Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012052020> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2012052020 endingPage "S83" @default.
- W2012052020 startingPage "S80" @default.
- W2012052020 abstract "Hepatocarcinogenic aromatic amines such as 4-aminoazobenzene derivatives and heterocyclic aromatic amines of cooked food origin were found to be liver-selective cytochrome P450IAZ (CYP1A2) inducers. Each aromatic amine showed different species-specificity among rodent experimental animals in terms of the extent of P450 induction. Carcinogenic susceptibility of an animal to the amine was well correlated with the activity and/or inducibility of CYP1A2 in the animals in the early initiation phase of the carcinogenesis. In hyperplastic nodules of rat liver, expression and induction of CYP1A2 as suppressed, especially in the placental form of glutathione S-transferase-positive foci. Despite the decrease of P450s including CYP1A2 in the rat liver bearing hyperplastic nodules, DNA adducts formed by a carcinogenic aromatic amine increased, as compared to the controls, suggesting that the activity of DNA repair enzyme(s) for the amine-derived DNA adducts might decrease in the hyperplastic nodules of rat liver. Treatment of rats with lead nitrate revealed a pattern of P450 expression in the liver similar to that observed with rats bearing hyperplastic nodules. These findings may provide valuable information on the roles of P450s in carcinogenic susceptibility of animals to aromatic amines and in the carcinogenic process." @default.
- W2012052020 created "2016-06-24" @default.
- W2012052020 creator A5012278399 @default.
- W2012052020 creator A5083755737 @default.
- W2012052020 date "1995-12-01" @default.
- W2012052020 modified "2023-10-18" @default.
- W2012052020 title "Induction of cytochrome P450 isoforms by carcinogenic aromatic amines and carcinogenic susceptibility of rodent animals" @default.
- W2012052020 doi "https://doi.org/10.1097/00008571-199512001-00006" @default.
- W2012052020 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7581495" @default.
- W2012052020 hasPublicationYear "1995" @default.
- W2012052020 type Work @default.
- W2012052020 sameAs 2012052020 @default.
- W2012052020 citedByCount "11" @default.
- W2012052020 countsByYear W20120520202019 @default.
- W2012052020 crossrefType "journal-article" @default.
- W2012052020 hasAuthorship W2012052020A5012278399 @default.
- W2012052020 hasAuthorship W2012052020A5083755737 @default.
- W2012052020 hasConcept C104317684 @default.
- W2012052020 hasConcept C114246631 @default.
- W2012052020 hasConcept C131779359 @default.
- W2012052020 hasConcept C132154277 @default.
- W2012052020 hasConcept C178790620 @default.
- W2012052020 hasConcept C181199279 @default.
- W2012052020 hasConcept C185592680 @default.
- W2012052020 hasConcept C2777278644 @default.
- W2012052020 hasConcept C2779043668 @default.
- W2012052020 hasConcept C2779838395 @default.
- W2012052020 hasConcept C526171541 @default.
- W2012052020 hasConcept C538909803 @default.
- W2012052020 hasConcept C55493867 @default.
- W2012052020 hasConcept C555283112 @default.
- W2012052020 hasConcept C86745063 @default.
- W2012052020 hasConcept C86803240 @default.
- W2012052020 hasConcept C87644729 @default.
- W2012052020 hasConceptScore W2012052020C104317684 @default.
- W2012052020 hasConceptScore W2012052020C114246631 @default.
- W2012052020 hasConceptScore W2012052020C131779359 @default.
- W2012052020 hasConceptScore W2012052020C132154277 @default.
- W2012052020 hasConceptScore W2012052020C178790620 @default.
- W2012052020 hasConceptScore W2012052020C181199279 @default.
- W2012052020 hasConceptScore W2012052020C185592680 @default.
- W2012052020 hasConceptScore W2012052020C2777278644 @default.
- W2012052020 hasConceptScore W2012052020C2779043668 @default.
- W2012052020 hasConceptScore W2012052020C2779838395 @default.
- W2012052020 hasConceptScore W2012052020C526171541 @default.
- W2012052020 hasConceptScore W2012052020C538909803 @default.
- W2012052020 hasConceptScore W2012052020C55493867 @default.
- W2012052020 hasConceptScore W2012052020C555283112 @default.
- W2012052020 hasConceptScore W2012052020C86745063 @default.
- W2012052020 hasConceptScore W2012052020C86803240 @default.
- W2012052020 hasConceptScore W2012052020C87644729 @default.
- W2012052020 hasIssue "Special Issue" @default.
- W2012052020 hasLocation W20120520201 @default.
- W2012052020 hasLocation W20120520202 @default.
- W2012052020 hasOpenAccess W2012052020 @default.
- W2012052020 hasPrimaryLocation W20120520201 @default.
- W2012052020 hasRelatedWork W16337247 @default.
- W2012052020 hasRelatedWork W2012052020 @default.
- W2012052020 hasRelatedWork W2030797357 @default.
- W2012052020 hasRelatedWork W2094019696 @default.
- W2012052020 hasRelatedWork W2138385035 @default.
- W2012052020 hasRelatedWork W2146307640 @default.
- W2012052020 hasRelatedWork W2166230193 @default.
- W2012052020 hasRelatedWork W2325459471 @default.
- W2012052020 hasRelatedWork W2394953872 @default.
- W2012052020 hasRelatedWork W2944139900 @default.
- W2012052020 hasVolume "5" @default.
- W2012052020 isParatext "false" @default.
- W2012052020 isRetracted "false" @default.
- W2012052020 magId "2012052020" @default.
- W2012052020 workType "article" @default.